Sleep and muscle recovery: Endocrinological and molecular basis for a new and promising hypothesis

Sleep and muscle recovery: Endocrinological and molecular basis for a new and promising hypothesis

Author Dattilo, Murilo Autor UNIFESP Google Scholar
Antunes, Hanna Karen Moreira Autor UNIFESP Google Scholar
Medeiros, Alessandra Autor UNIFESP Google Scholar
Mônico-Neto, Marcos Autor UNIFESP Google Scholar
Souza, Heitor Soares de Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Mello, Marco Tulio de Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Sleep is essential for the cellular, organic and systemic functions of an organism, with its absence being potentially harmful to health and changing feeding behavior, glucose regulation, blood pressure, cognitive processes and some hormonal axes. Among the hormonal changes, there is an increase in cortisol (humans) and corticosterone (rats) secretion, and a reduction in testosterone and Insulin-like Growth Factor 1, favoring the establishment of a highly proteolytic environment. Consequently, we hypothesized that sleep debt decreases the activity of protein synthesis pathways and increases the activity of degradation pathways, favoring the loss of muscle mass and thus hindering muscle recovery after damage induced by exercise, injuries and certain conditions associated with muscle atrophy, such as sarcopenia and cachexia. (C) 2011 Elsevier B.V. All rights reserved.
Language English
Sponsor Associacao Fundo de Incentivo a Pesquisa (AFIP)
Centro de Estudos em psicobiologia e Exercicio Acidentes (CEPE)
Centro de Estudo Multidisciplinar em Sonolencia e Acidentes (CEMSA)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Grant number FAPESP: 98/14303-3
FAPESP: 2009/11056-1
Date 2011-08-01
Published in Medical Hypotheses. Edinburgh: Churchill Livingstone, v. 77, n. 2, p. 220-222, 2011.
ISSN 0306-9877 (Sherpa/Romeo, impact factor)
Publisher Churchill Livingstone
Extent 220-222
Access rights Closed access
Type Article
Web of Science ID WOS:000294039100019

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