Aerobic Exercise Training-Induced Left Ventricular Hypertrophy Involves Regulatory MicroRNAs, Decreased Angiotensin-Converting Enzyme-Angiotensin II, and Synergistic Regulation of Angiotensin-Converting Enzyme 2-Angiotensin (1-7)

Aerobic Exercise Training-Induced Left Ventricular Hypertrophy Involves Regulatory MicroRNAs, Decreased Angiotensin-Converting Enzyme-Angiotensin II, and Synergistic Regulation of Angiotensin-Converting Enzyme 2-Angiotensin (1-7)

Autor Fernandes, Tiago Google Scholar
Hashimoto, Nara Y. Google Scholar
Magalhaes, Flavio C. Google Scholar
Fernandes, Fernanda Barrinha Autor UNIFESP Google Scholar
Casarini, Dulce Elena Autor UNIFESP Google Scholar
Carmona, Adriana Karaoglanovic Autor UNIFESP Google Scholar
Krieger, Jose E. Google Scholar
Phillips, M. Ian Google Scholar
Oliveira, Edilamar M. Google Scholar
Instituição Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Keck Grad Inst
Resumo Aerobic exercise training leads to a physiological, nonpathological left ventricular hypertrophy; however, the underlying biochemical and molecular mechanisms of physiological left ventricular hypertrophy are unknown. the role of microRNAs regulating the classic and the novel cardiac renin-angiotensin (Ang) system was studied in trained rats assigned to 3 groups: (1) sedentary; (2) swimming trained with protocol 1 (T1, moderate-volume training); and (3) protocol 2 (T2, high-volume training). Cardiac Ang I levels, Ang-converting enzyme (ACE) activity, and protein expression, as well as Ang II levels, were lower in T1 and T2; however, Ang II type 1 receptor mRNA levels (69% in T1 and 99% in T2) and protein expression (240% in T1 and 300% in T2) increased after training. Ang II type 2 receptor mRNA levels (220%) and protein expression (332%) were shown to be increased in T2. in addition, T1 and T2 were shown to increase ACE2 activity and protein expression and Ang (1-7) levels in the heart. Exercise increased microRNA-27a and 27b, targeting ACE and decreasing microRNA-143 targeting ACE2 in the heart. Left ventricular hypertrophy induced by aerobic training involves microRNA regulation and an increase in cardiac Ang II type 1 receptor without the participation of Ang II. Parallel to this, an increase in ACE2, Ang (1-7), and Ang II type 2 receptor in the heart by exercise suggests that this nonclassic cardiac renin-angiotensin system counteracts the classic cardiac renin-angiotensin system. These findings are consistent with a model in which exercise may induce left ventricular hypertrophy, at least in part, altering the expression of specific microRNAs targeting renin-angiotensin system genes. Together these effects might provide the additional aerobic capacity required by the exercised heart. (Hypertension. 2011;58:182-189.).
Assunto aerobic exercise training
cardiac hypertrophy
renin angiotensin system
microRNAs
angiotensin II receptors
ACE2
angiotensin (1-7)
Idioma Inglês
Financiador Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Cientifico e Technologico-Pos-Doutorado
Conselho Nacional de Desenvolvimento Cientifico e Technologico, Brazil
Coordenacao de Aperfeicoamento de Pessoal de Nivel
National Institutes of Health
Número do financiamento FAPESP: 2009/18370-3
FAPESP: 07/56771-4
Conselho Nacional de Desenvolvimento Cientifico e Technologico-Pos-Doutorado: 200994/2007-7
National Institutes of Health: 1 R01 HL 077602
Data 2011-08-01
Publicado em Hypertension. Philadelphia: Lippincott Williams & Wilkins, v. 58, n. 2, p. 182-U121, 2011.
ISSN 0194-911X (Sherpa/Romeo, fator de impacto)
Editor Lippincott Williams & Wilkins
Extensão 182-U121
Fonte http://dx.doi.org/10.1161/HYPERTENSIONAHA.110.168252
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000292918000021
URI http://repositorio.unifesp.br/handle/11600/33906

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