Bacterial Sepsis in Brazilian Children: A Trend Analysis from 1992 to 2006

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dc.contributor.author Mangia, Cristina Malzoni Ferreira [UNIFESP]
dc.contributor.author Kissoon, Niranjan
dc.contributor.author Branchini, Otavio Augusto
dc.contributor.author Andrade, Maria Cristina [UNIFESP]
dc.contributor.author Kopelman, Benjamin Israel [UNIFESP]
dc.contributor.author Carcillo, Joe
dc.date.accessioned 2016-01-24T14:16:52Z
dc.date.available 2016-01-24T14:16:52Z
dc.date.issued 2011-06-03
dc.identifier http://dx.doi.org/10.1371/journal.pone.0014817
dc.identifier.citation Plos One. San Francisco: Public Library Science, v. 6, n. 6, 9 p., 2011.
dc.identifier.issn 1932-6203
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/33796
dc.description.abstract Background: the objective of this study was to determine the epidemiology of hospitalized pediatric sepsis in Brazil (19922006) and to compare mortality caused by sepsis to that caused by other major childhood diseases.Methods and Findings: We performed a retrospective descriptive study of hospital admissions using a government database of all hospital affiliated with the Brazilian health system. We studied all hospitalizations in children from 28 days through 19 years with diagnosis of bacterial sepsis defined by the criteria of the International Classification of Diseases (ICD), (Appendix S1). Based on the data studied from 1992 through 2006, the pediatric hospital mortality rate was 1.23% and there were 556,073 pediatric admissions with bacterial sepsis with a mean mortality rate of 19.9%. There was a case reduction of 67% over. 1992-2006 (p<0.001); however, the mortality rate remained unchanged (from 1992-1996, 20.5%; and from 20022006, 19.7%). Sepsis-hospital mortality rate was substantially higher than pneumonia (0.5%), HIV (3.3%), diarrhea (0.3%), undernutrition (2.3%), malaria (0.2%) and measles (0.7%). the human development index (HDI) and mortality rates (MR) by region were: North region 0.76 and 21.7%; Northeast region 0.72 and 27.1%; Central-West 0.81 and 23.5%; South region 0.83 and 12.2% and Southeast region 0.82 and 14.8%, respectively.Conclusions: We concluded that sepsis remains an important health problem in children in Brazil. the institution of universal primary care programs has been associated with substantially reduced sepsis incidence and therefore deaths; however, hospital mortality rates in children with sepsis remain unchanged. Implementation of additional health initiatives to reduce sepsis mortality in hospitalized patients could have great impact on childhood mortality rates in Brazil. en
dc.format.extent 9
dc.language.iso eng
dc.publisher Public Library Science
dc.relation.ispartof Plos One
dc.rights Acesso aberto
dc.title Bacterial Sepsis in Brazilian Children: A Trend Analysis from 1992 to 2006 en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Univ British Columbia
dc.contributor.institution Hosp Emilio Ribas
dc.contributor.institution Univ Pittsburgh
dc.description.affiliation Universidade Federal de São Paulo, Dept Pediat, Escola Paulista Med, São Paulo, Brazil
dc.description.affiliation Univ British Columbia, Dept Pediat, Div Crit Care, Child & Family Res Inst, Vancouver, BC V6T 1W5, Canada
dc.description.affiliation Hosp Emilio Ribas, São Paulo, Brazil
dc.description.affiliation Univ Pittsburgh, Sch Med, Dept Anesthesiol & Crit Care Med, Pittsburgh, PA 15261 USA
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Pediat, Escola Paulista Med, São Paulo, Brazil
dc.identifier.file WOS000291355500001.pdf
dc.identifier.doi 10.1371/journal.pone.0014817
dc.description.source Web of Science
dc.identifier.wos WOS:000291355500001



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