Bacterial Sepsis in Brazilian Children: A Trend Analysis from 1992 to 2006

Bacterial Sepsis in Brazilian Children: A Trend Analysis from 1992 to 2006

Author Mangia, Cristina Malzoni Ferreira Autor UNIFESP Google Scholar
Kissoon, Niranjan Google Scholar
Branchini, Otavio Augusto Google Scholar
Andrade, Maria Cristina Autor UNIFESP Google Scholar
Kopelman, Benjamin Israel Autor UNIFESP Google Scholar
Carcillo, Joe Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Univ British Columbia
Hosp Emilio Ribas
Univ Pittsburgh
Abstract Background: the objective of this study was to determine the epidemiology of hospitalized pediatric sepsis in Brazil (19922006) and to compare mortality caused by sepsis to that caused by other major childhood diseases.Methods and Findings: We performed a retrospective descriptive study of hospital admissions using a government database of all hospital affiliated with the Brazilian health system. We studied all hospitalizations in children from 28 days through 19 years with diagnosis of bacterial sepsis defined by the criteria of the International Classification of Diseases (ICD), (Appendix S1). Based on the data studied from 1992 through 2006, the pediatric hospital mortality rate was 1.23% and there were 556,073 pediatric admissions with bacterial sepsis with a mean mortality rate of 19.9%. There was a case reduction of 67% over. 1992-2006 (p<0.001); however, the mortality rate remained unchanged (from 1992-1996, 20.5%; and from 20022006, 19.7%). Sepsis-hospital mortality rate was substantially higher than pneumonia (0.5%), HIV (3.3%), diarrhea (0.3%), undernutrition (2.3%), malaria (0.2%) and measles (0.7%). the human development index (HDI) and mortality rates (MR) by region were: North region 0.76 and 21.7%; Northeast region 0.72 and 27.1%; Central-West 0.81 and 23.5%; South region 0.83 and 12.2% and Southeast region 0.82 and 14.8%, respectively.Conclusions: We concluded that sepsis remains an important health problem in children in Brazil. the institution of universal primary care programs has been associated with substantially reduced sepsis incidence and therefore deaths; however, hospital mortality rates in children with sepsis remain unchanged. Implementation of additional health initiatives to reduce sepsis mortality in hospitalized patients could have great impact on childhood mortality rates in Brazil.
Language English
Date 2011-06-03
Published in Plos One. San Francisco: Public Library Science, v. 6, n. 6, 9 p., 2011.
ISSN 1932-6203 (Sherpa/Romeo, impact factor)
Publisher Public Library Science
Extent 9
Origin http://dx.doi.org/10.1371/journal.pone.0014817
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000291355500001
URI http://repositorio.unifesp.br/handle/11600/33796

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