Impact of thymidylate synthase promoter and DNA repair gene polymorphisms on susceptibility to childhood acute lymphoblastic leukemia

Impact of thymidylate synthase promoter and DNA repair gene polymorphisms on susceptibility to childhood acute lymphoblastic leukemia

Author Canalle, Renata Google Scholar
Silveira, Vanessa S. Google Scholar
Scrideli, Carlos Alberto Google Scholar
Queiroz, Rosane G. P. Google Scholar
Lopes, Luiz Fernando Google Scholar
Tone, Luiz Gonzaga Google Scholar
Institution Universidade de São Paulo (USP)
Univ Fed Piaui
Universidade Federal de São Paulo (UNIFESP)
Abstract The aim of this study was to evaluate the frequency of polymorphisms in the TYMS, XRCC1, and ERCC2 DNA repair genes in pediatric patients with acute lymphoblastic leukemia using polymerase chain reaction (PCR) and PCR-restriction fragment length polymorphism (RFLP) approaches. the study was conducted in 206 patients and 364 controls from a Brazilian population. No significant differences were observed among the analyzed groups regarding XRCC1 codon 399 and codon 194 and ERCC2 codon 751 and codon 312 polymorphisms. the TYMS 3R variant allele was significantly associated with a reduced risk of childhood ALL, represented by the sum of heterozygous and polymorphic homozygous genotypes (odds ratio 0.60; 95% confidence interval 0.37-0.99). the results suggest that polymorphism in TYMS may play a protective role against the development of childhood ALL.
Keywords Genetic polymorphisms
TYMS
XRCC1
ERCC2
susceptibility
childhood ALL
Language English
Date 2011-06-01
Published in Leukemia & Lymphoma. London: Informa Healthcare, v. 52, n. 6, p. 1118-1126, 2011.
ISSN 1042-8194 (Sherpa/Romeo, impact factor)
Publisher Informa Healthcare
Extent 1118-1126
Origin http://dx.doi.org/10.3109/10428194.2011.559672
Access rights Closed access
Type Article
Web of Science ID WOS:000290869100027
URI http://repositorio.unifesp.br/handle/11600/33791

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