Vaccine antibodies and T- and B-cell interaction in juvenile systemic lupus erythematosus

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dc.contributor.author Miyamoto, M.
dc.contributor.author Ono, E.
dc.contributor.author Barbosa, C. P. L. [UNIFESP]
dc.contributor.author Terreri, M. T. R. A. [UNIFESP]
dc.contributor.author Hilario, M. O. E. [UNIFESP]
dc.contributor.author Salomão, Reinaldo [UNIFESP]
dc.contributor.author Moraes-Pinto, M. I. de [UNIFESP]
dc.date.accessioned 2016-01-24T14:16:52Z
dc.date.available 2016-01-24T14:16:52Z
dc.date.issued 2011-06-01
dc.identifier http://dx.doi.org/10.1177/0961203310397409
dc.identifier.citation Lupus. London: Sage Publications Ltd, v. 20, n. 7, p. 736-744, 2011.
dc.identifier.issn 0961-2033
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/33786
dc.description.abstract Both systemic lupus erythematosus (SLE) and its treatment can cause immunosuppression and a decreased response to vaccination. We evaluated 30 children and adolescents with SLE, and 14 age-matched healthy subjects (control group) regarding immunophenotyping and lymphocyte apoptosis by flow cytometry, while measles and tetanus antibodies were measured by enzyme-linked immunosorbent assay (ELISA). the SLE group was divided according to disease activity into inactive SLE and active SLE. Individuals with active SLE had lower CD4+ T and natural killer (NK) cells/mm(3) than the control group. Active and inactive SLE individuals had more CD38 molecules/CD8+ T cells and more CD4+ T, CD8+ T and B cells in apoptosis (as assessed by caspase-3 expression) than the control group. Patients with active SLE had a diminished CD28 expression on both CD4+ T and on CD8+ T cells and a higher CD86 expression on B cells than the control group. Measles antibody levels in the SLE groups were similar to the control group. in contrast, tetanus antibody levels were lower in the SLE groups than in the control group. the latter also directly correlated with the CD4+ T-cell and NK-cell counts from SLE patients (regression coefficient, 2.686 and 1.782; p = 0.010 and p = 0.039, respectively). We concluded that despite being up-to-date for tetanus vaccine, SLE patients presented with a poor immune response to tetanus vaccine. Lupus (2011) 20, 736-744. en
dc.description.sponsorship Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent 736-744
dc.language.iso eng
dc.publisher Sage Publications Ltd
dc.relation.ispartof Lupus
dc.rights Acesso restrito
dc.subject apoptosis en
dc.subject lymphocyte activation en
dc.subject measles antibodies en
dc.subject systemic lupus erythematosus en
dc.subject tetanus antibodies en
dc.title Vaccine antibodies and T- and B-cell interaction in juvenile systemic lupus erythematosus en
dc.type Artigo
dc.rights.license http://www.uk.sagepub.com/aboutus/openaccess.htm
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo, Res Lab, Div Pediat Infect Dis, Dept Pediat, BR-04039032 São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Div Allergy Clin Immunol & Rheumatol, Dept Pediat, BR-04039032 São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Div Infect Dis, Dept Med, BR-04039032 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Res Lab, Div Pediat Infect Dis, Dept Pediat, BR-04039032 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Div Allergy Clin Immunol & Rheumatol, Dept Pediat, BR-04039032 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Div Infect Dis, Dept Med, BR-04039032 São Paulo, Brazil
dc.description.sponsorshipID FAPESP: 04/15316-4
dc.description.sponsorshipID FAPESP: 04/15317-0
dc.identifier.doi 10.1177/0961203310397409
dc.description.source Web of Science
dc.identifier.wos WOS:000290759300010



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