Exercise Paradigms to Study Brain Injury Recovery in Rodents

Exercise Paradigms to Study Brain Injury Recovery in Rodents

Author Arida, Ricardo Mario Autor UNIFESP Google Scholar
Scorza, Fulvio Alexandre Autor UNIFESP Google Scholar
Silva, Sergio Gomes da Autor UNIFESP Google Scholar
Cysneiros, Roberta Monterazzo Google Scholar
Cavalheiro, Esper Abrao Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Univ Presbiteriana Mackenzie
Abstract Arida RM, Scorza FA, Gomes da Silva S, Cysneiros RM, Cavalheiro EA: Exercise paradigms to study brain injury recovery in rodents. Am J Phys Med Rehabil 2011;90:452-465.Exercise has been found to influence molecular systems important for maintaining neural function and plasticity as well as treatment of neurologic disorders. the stimuli required to elicit plasticity are thought to be activity dependent. Several protocols of physical exercise have been used to explore its effects on brain function. However, it is becoming increasingly recognized that no single physical exercise model is likely to fulfill all therapeutic needs. Varied interpretations of data derived from animal models have given rise to the lack of uniformity in the description and control of various features of the physical exercise stimulus, ranging from low to high intensity, intermittent to sustained, short to long durations, and different modes of activity. This article first describes the characteristics of the most frequently used animal models and goes on to review brain plasticity in intact animals and the usefulness of these models for the study of brain disorders. in this regard, animal models that investigate the beneficial effects of exercise on the brain before and after brain injury are discussed. A challenge for future studies is to better evaluate the usefulness of physical exercise protocols for preventing or treating brain disorders.
Keywords Physical Activity
Exercise
Animal Model
Brain
Plasticity
Neurodegenerative Disease
Language English
Sponsor Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Cooperacao Interinstitucional de Apoio a Pesquisa sobre o Cerebro (ClnAPCe)
Instituto Nacional de Neurociencia Translacional (INNT) (Brazil)
Date 2011-06-01
Published in American Journal of Physical Medicine & Rehabilitation. Philadelphia: Lippincott Williams & Wilkins, v. 90, n. 6, p. 452-465, 2011.
ISSN 0894-9115 (Sherpa/Romeo, impact factor)
Publisher Lippincott Williams & Wilkins
Extent 452-465
Origin http://dx.doi.org/10.1097/PHM.0b013e3182063a9c
Access rights Closed access
Type Review
Web of Science ID WOS:000290433200003
URI http://repositorio.unifesp.br/handle/11600/33779

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