Pneumococcal Nasopharyngeal Carriage Among Infants Born to Human Immunodeficiency Virus-infected Mothers Immunized With Pneumococcal Polysaccharide Vaccine During Gestation

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dc.contributor.author Almeida, Volia de Carvalho
dc.contributor.author Negrini, Bento V. M.
dc.contributor.author Cervi, Maria C.
dc.contributor.author Isaac, Marcia de L.
dc.contributor.author Mussi-Pinhata, Marisa M.
dc.date.accessioned 2016-01-24T14:16:51Z
dc.date.available 2016-01-24T14:16:51Z
dc.date.issued 2011-06-01
dc.identifier http://dx.doi.org/10.1097/INF.0b013e31820a1ec6
dc.identifier.citation Pediatric Infectious Disease Journal. Philadelphia: Lippincott Williams & Wilkins, v. 30, n. 6, p. 466-470, 2011.
dc.identifier.issn 0891-3668
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/33778
dc.description.abstract Background: We have previously shown that 23-valent pneumococcal polysaccharide vaccine (PPV) is immunogenic in human immunodeficiency virus (HIV)-infected mothers and provides vaccine-induced antibodies to the infant. We compared the nasopharyngeal pneumococcal colonization (NPC) rates in <6-month-old infants born to HIV-infected mothers, according to immunization with PPV during pregnancy.Methods: NPC was evaluated in 45 term infants born to vaccinated women (PPV+) and in 60 infants in a control group (PPV-), at 2 months (+/- 30 days), 4 months (+/- 30 days), and 6 months (+/- 30 days) of age.Results: A total of 82 infants completed the study (at least 2 of 3 evaluations), 35 (77%) in the PPV+ and 47 (78.3%) in the PPV- groups, respectively. Infant gender, HIV infection status, number of adults, children, and smokers in the household, day-care attendance, occurrence of respiratory signs, and cotrimoxazole use were similar in both groups. NPC rates increased equally with age in both groups (2 months = 26.7% vs. 25.6%; 4 months = 34.5% vs. 38.6%; 6 months = 38.7% vs. 56.3%, in PPV+ and PPV-, respectively). After controlling for potential confounders, we found no association between maternal vaccination and infant pneumococcal carriage (adjusted odds ratio = 0.70; 95% confidence interval: 0.23, 2.21)Conclusions: Vaccination of HIV-infected mothers with PPV did not protect infants younger than 6 months of age from nasopharyngeal pneumococcal carriage. en
dc.description.sponsorship Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent 466-470
dc.language.iso eng
dc.publisher Lippincott Williams & Wilkins
dc.relation.ispartof Pediatric Infectious Disease Journal
dc.rights Acesso restrito
dc.subject infant en
dc.subject Streptococcus pneumoniae en
dc.subject colonization en
dc.subject 23-valent polysaccharide pneumococcal vaccine en
dc.subject maternal immunization en
dc.subject pneumococcal carriage en
dc.title Pneumococcal Nasopharyngeal Carriage Among Infants Born to Human Immunodeficiency Virus-infected Mothers Immunized With Pneumococcal Polysaccharide Vaccine During Gestation en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Carlos (UFSCar)
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Univ Fed Sao Carlos, Dept Med Hlth, BR-13565905 Sao Carlos, SP, Brazil
dc.description.affiliation Univ Fed Sao Carlos, Ctr Biol Sci, BR-13565905 Sao Carlos, SP, Brazil
dc.description.affiliation Univ São Paulo, Fac Med Ribeirao Preto, Dept Pediat, São Paulo, Brazil
dc.description.sponsorshipID FAPESP: 02/01294-3
dc.identifier.doi 10.1097/INF.0b013e31820a1ec6
dc.description.source Web of Science
dc.identifier.wos WOS:000291095600007



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