Pneumococcal Nasopharyngeal Carriage Among Infants Born to Human Immunodeficiency Virus-infected Mothers Immunized With Pneumococcal Polysaccharide Vaccine During Gestation

Pneumococcal Nasopharyngeal Carriage Among Infants Born to Human Immunodeficiency Virus-infected Mothers Immunized With Pneumococcal Polysaccharide Vaccine During Gestation

Author Almeida, Volia de Carvalho Google Scholar
Negrini, Bento V. M. Google Scholar
Cervi, Maria C. Google Scholar
Isaac, Marcia de L. Google Scholar
Mussi-Pinhata, Marisa M. Google Scholar
Institution Universidade Federal de São Carlos (UFSCar)
Universidade Federal de São Paulo (UNIFESP)
Abstract Background: We have previously shown that 23-valent pneumococcal polysaccharide vaccine (PPV) is immunogenic in human immunodeficiency virus (HIV)-infected mothers and provides vaccine-induced antibodies to the infant. We compared the nasopharyngeal pneumococcal colonization (NPC) rates in <6-month-old infants born to HIV-infected mothers, according to immunization with PPV during pregnancy.Methods: NPC was evaluated in 45 term infants born to vaccinated women (PPV+) and in 60 infants in a control group (PPV-), at 2 months (+/- 30 days), 4 months (+/- 30 days), and 6 months (+/- 30 days) of age.Results: A total of 82 infants completed the study (at least 2 of 3 evaluations), 35 (77%) in the PPV+ and 47 (78.3%) in the PPV- groups, respectively. Infant gender, HIV infection status, number of adults, children, and smokers in the household, day-care attendance, occurrence of respiratory signs, and cotrimoxazole use were similar in both groups. NPC rates increased equally with age in both groups (2 months = 26.7% vs. 25.6%; 4 months = 34.5% vs. 38.6%; 6 months = 38.7% vs. 56.3%, in PPV+ and PPV-, respectively). After controlling for potential confounders, we found no association between maternal vaccination and infant pneumococcal carriage (adjusted odds ratio = 0.70; 95% confidence interval: 0.23, 2.21)Conclusions: Vaccination of HIV-infected mothers with PPV did not protect infants younger than 6 months of age from nasopharyngeal pneumococcal carriage.
Keywords infant
Streptococcus pneumoniae
colonization
23-valent polysaccharide pneumococcal vaccine
maternal immunization
pneumococcal carriage
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Grant number FAPESP: 02/01294-3
Date 2011-06-01
Published in Pediatric Infectious Disease Journal. Philadelphia: Lippincott Williams & Wilkins, v. 30, n. 6, p. 466-470, 2011.
ISSN 0891-3668 (Sherpa/Romeo, impact factor)
Publisher Lippincott Williams & Wilkins
Extent 466-470
Origin http://dx.doi.org/10.1097/INF.0b013e31820a1ec6
Access rights Closed access
Type Article
Web of Science ID WOS:000291095600007
URI http://repositorio.unifesp.br/handle/11600/33778

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