Exposure to maternal smoking during fetal life affects food preferences in adulthood independent of the effects of intrauterine growth restriction

Exposure to maternal smoking during fetal life affects food preferences in adulthood independent of the effects of intrauterine growth restriction

Author Ayres, C. Google Scholar
Silveira, P. P. Google Scholar
Barbieri, M. A. Google Scholar
Portella, A. K. Google Scholar
Bettiol, H. Google Scholar
Agranonik, M. Google Scholar
Silva, A. A. Google Scholar
Goldani, M. Z. Google Scholar
Institution Univ Fed Rio Grande do Sul
Universidade Federal de São Paulo (UNIFESP)
Univ Fed Maranhao
Abstract Experimental animal studies have shown that nicotine exposure during gestation alters the expression of fetal hypothalamic neuropeptides involved in the control of appetite. We aimed to determine whether the exposure to maternal smoking during gestation in humans is associated with an altered feeding behavior of the adult offspring. A longitudinal prospective cohort study was conducted including all births from Ribeirao Preto (São Paulo, Brazil) between 1978 and 1979. At 24 years of age, a representative random sample was re-evaluated and divided into groups exposed (n = 424) or not (n = 1586) to maternal smoking during gestation. Feeding behavior was analyzed using a food frequency questionnaire. Covariance analysis was used for continuous data and the chi(2) test for categorical data. Results were adjusted for birth weight ratio, body mass index, gender, physical activity and smoking, as well as maternal and subjects' schooling. Individuals exposed to maternal smoking during gestation ate more carbohydrates than proteins (as per the carbohydrate-to-protein ratio) than non-exposed individuals. There were no differences in the consumption of the macronutrients themselves. We propose that this adverse fetal life event programs the individual's physiology and metabolism persistently, leading to an altered feeding behavior that could contribute to the development of chronic diseases in the long term.
Keywords DOHaD
feeding behavior
programming
tobacco smoking during gestation
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Date 2011-06-01
Published in Journal of Developmental Origins of Health and Disease. Cambridge: Cambridge Univ Press, v. 2, n. 3, p. 162-167, 2011.
ISSN 2040-1744 (Sherpa/Romeo, impact factor)
Publisher Cambridge Univ Press
Extent 162-167
Origin http://dx.doi.org/10.1017/S204017441100016X
Access rights Closed access
Type Article
Web of Science ID WOS:000291564200004
URI http://repositorio.unifesp.br/handle/11600/33769

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