Adhesio interthalamica alterations in schizophrenia spectrum disorders: A systematic review and meta-analysis

Adhesio interthalamica alterations in schizophrenia spectrum disorders: A systematic review and meta-analysis

Author Trzesniak, Clarissa Google Scholar
Kempton, Matthew J. Google Scholar
Busatto, Geraldo F. Google Scholar
Oliveira, Irismar Reis de Google Scholar
Galvao-de Almeida, Amanda Autor UNIFESP Google Scholar
Kambeitz, Joseph Google Scholar
Freitas Ferrari, Maria Cecilia Google Scholar
Santos Filho, Alaor Google Scholar
Chagas, Marcos H. N. Google Scholar
Zuardi, Antonio W. Google Scholar
Hallak, Jaime E. C. Google Scholar
McGuire, Phillip K. Google Scholar
Crippa, Jose Alexandre S. Google Scholar
Institution Universidade de São Paulo (USP)
Kings Coll London
Universidade Federal da Bahia (UFBA)
Universidade Federal de São Paulo (UNIFESP)
LiNC
Abstract Magnetic resonance imaging (MRI) studies have reported a variety of brain abnormalities in association with schizophrenia. These include a higher prevalence of an absent adhesio interthalamica (Al; also known massa intermedia), a gray matter junction that is present between the two thalami in approximately 80% of healthy subjects. in this meta-analytic review, we describe and discuss the main Al MRI findings in schizophrenia spectrum disorders (SSDs) to date. the MEDLINE and ISI Web of Knowledge(SM) databases were searched up to December 2010, for studies that used MRI to assess Al in patients with SSD and controls. From fourteen potential reports, eleven were eligible to be part of the current review. These studies included 822 patients with SSD and 718 healthy volunteers. There was a large degree of variability in the MRI methods they employed. Patients with SSD had a higher prevalence of absent Al than healthy volunteers (odds ratio = 1.98; 95% confidence interval 1.33-2.94: p=0.0008). This association was evident in both male and female SSD subjects, and there was no evidence that the prevalence was related to age or duration of illness. the significance of the absence of an Al for SSD may be clarified by studies in large, longitudinal community-based samples using standardized methods. (C) 2011 Elsevier Inc. All rights reserved.
Keywords Adhesio interthalamica
Magnetic resonance imaging
Massa intermedia
Meta-analysis
Schizophrenia
Thalamus
Language English
Sponsor Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Grant number CAPES: 5797/09-8
Date 2011-06-01
Published in Progress in Neuro-psychopharmacology & Biological Psychiatry. Oxford: Pergamon-Elsevier B.V., v. 35, n. 4, p. 877-886, 2011.
ISSN 0278-5846 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 877-886
Origin http://dx.doi.org/10.1016/j.pnpbp.2010.12.024
Access rights Closed access
Type Review
Web of Science ID WOS:000291848000009
URI http://repositorio.unifesp.br/handle/11600/33766

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