Inflammatory mediator gene polymorphisms and gestational diabetes: a review of the literature

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dc.contributor.author Daher, Silvia [UNIFESP]
dc.contributor.author Torloni, Maria Regina [UNIFESP]
dc.contributor.author Gueuvoghlanian-Silva, Barbara Yasmin [UNIFESP]
dc.contributor.author Moron, Antonio Fernandes [UNIFESP]
dc.contributor.author Mattar, Rosiane [UNIFESP]
dc.date.accessioned 2016-01-24T14:16:50Z
dc.date.available 2016-01-24T14:16:50Z
dc.date.issued 2011-06-01
dc.identifier http://dx.doi.org/10.1016/j.jri.2011.04.008
dc.identifier.citation Journal of Reproductive Immunology. Clare: Elsevier B.V., v. 90, n. 1, p. 111-116, 2011.
dc.identifier.issn 0165-0378
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/33763
dc.description.abstract The incidence of gestational diabetes (GD) is rising worldwide, in parallel with obesity and type 2 diabetes. Obesity and GD are conditions that have in common a state of chronic, low-grade subclinical inflammation characterized by abnormal production of cytokines and mediators. Genetic polymorphisms may influence the production of inflammatory mediators and predispose to different disorders, including diabetes. the aim of this study was to review the existing literature on the relationship between inflammatory mediator gene polymorphisms and GD. the search in PubMed was restricted to articles published in English, from January 1990 to December 2010. Eight studies were included. These publications evaluated 13 different SNPs and six inflammatory mediators in the blood of women with GD. Gene polymorphisms related to leptin, mannose-binding lectin (MBL) and RAGE (receptor for advanced glycation end products) were individually evaluated in a single study each. Leptin and MBL plasma levels were also evaluated in two studies. the participants included in the studies were ethnically different, but matched with controls. Different criteria were adopted to select the participants. Seven of the eight studies included took into consideration the BMI of patients and controls. Due to the heterogeneity and limited number of studies on GD and inflammatory gene polymorphisms, we could not pool together any of the results or perform any additional analyses of the existing data. Since the existing findings come from isolated studies with mostly small sample sizes, there is a need for new, larger, properly designed studies of good methodological quality. (C) 2011 Elsevier Ireland Ltd. All rights reserved. en
dc.format.extent 111-116
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof Journal of Reproductive Immunology
dc.rights Acesso restrito
dc.subject Genetic polymorphisms en
dc.subject Gestational diabetes en
dc.subject Inflammation en
dc.subject Adiponectin en
dc.subject Cytokines en
dc.title Inflammatory mediator gene polymorphisms and gestational diabetes: a review of the literature en
dc.type Artigo
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo, Dept Obstet, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Obstet, São Paulo, Brazil
dc.identifier.doi 10.1016/j.jri.2011.04.008
dc.description.source Web of Science
dc.identifier.wos WOS:000293324100017



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