Expression of Bone Morphogenetic Protein-1 in vaginal tissue of women with severe pelvic organ prolapse

Expression of Bone Morphogenetic Protein-1 in vaginal tissue of women with severe pelvic organ prolapse

Author Bortolini, Maria A. T. Autor UNIFESP Google Scholar
Shynlova, Oksana Google Scholar
Drutz, Harold P. Google Scholar
Girao, Manoel J. B. C. Autor UNIFESP Google Scholar
Castro, Rodrigo A. Autor UNIFESP Google Scholar
Lye, Stephen Google Scholar
Alarab, May Google Scholar
Institution Univ Toronto
Mt Sinai Hosp
Universidade Federal de São Paulo (UNIFESP)
Abstract OBJECTIVES: To analyze the differential gene and protein expression of Bone Morphogenetic Protein-1 in vaginal tissue of women with advanced pelvic organ prolapse and controls.STUDY DESIGN: We sampled the anterior vaginal wall of 39 premenopausal (23 patients and 16 controls), and 18 postmenopausal women (13 patients and 5 controls) during hysterectomy. Total mRNAs and proteins were quantified by real-time RT-PCR and immunoblotting.RESULTS: Bone Morphogenetic Protein-1 gene expression was decreased in pre- and postmenopausal pelvic organ prolapse patients compared with asymptomatic women (P = .01). the expression of 130 kDa, 92.5 kDa, and 82.5 kDa isoforms of Bone Morphogenetic Protein-1 were down-regulated in postmenopausal patients (P = .01), whereas the 130 kDa isoform expression was up-regulated in premenopausal patients (P = .009), when compared with respective controls.CONCLUSION: the Bone Morphogenetic Protein-1 expression in human vagina was altered in patients with severe pelvic organ prolapse and influenced by menopausal status. Dysregulation of Bone Morphogenetic Protein-1 may contribute for a deficient vaginal connective tissue and support.
Keywords Bone Morphogenetic Protein-1
extracellular matrix
pelvic organ prolapse
procollagen C proteinase
vagina
Language English
Date 2011-06-01
Published in American Journal of Obstetrics and Gynecology. New York: Mosby-Elsevier, v. 204, n. 6, 8 p., 2011.
ISSN 0002-9378 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 8
Origin http://dx.doi.org/10.1016/j.ajog.2011.01.021
Access rights Closed access
Type Article
Web of Science ID WOS:000291477300042
URI http://repositorio.unifesp.br/handle/11600/33750

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