Cellular death but not genetic damage in oral mucosa cells after exposure to digital lateral radiography

Cellular death but not genetic damage in oral mucosa cells after exposure to digital lateral radiography

Author Ribeiro, Daniel A. Autor UNIFESP Google Scholar
Sannomiya, Eduardo K. Google Scholar
Pozzi, Renan Autor UNIFESP Google Scholar
Miranda, Sandra R. Autor UNIFESP Google Scholar
Angelieri, Fernanda Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
São Paulo Methodist Univ
Abstract The aim of the present study was to evaluate DNA damage (micronucleus) and cellular death (pyknosis, karyolysis, and karyorrhexis) in exfoliated buccal mucosa cells from individuals following digital lateral radiography. A total of 30 healthy patients (15 men and 15 women) indicated to the orthodontic therapy were submitted to digital lateral X-ray. Exfoliated oral mucosa cells were collected immediately before the X-ray exposure and after 10 days. the results pointed out no significant statistically differences (p > 0.05) of micronucleated oral mucosa cells. On the other hand, X-ray was able to increase other nuclear alterations closely related to cytotoxicity such as karyorrhexis, pyknosis, and karyolysis. in summary, these data indicate that exposure to digital lateral radiography may not be a factor that induced chromosomal damage, but it is able to promote cytotoxicity.
Keywords Buccal mucosa cells
Digital lateral radiograph
Micronucleus test
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Grant number FAPESP: 07/01228-4
Date 2011-06-01
Published in Clinical Oral Investigations. Heidelberg: Springer Heidelberg, v. 15, n. 3, p. 357-360, 2011.
ISSN 1432-6981 (Sherpa/Romeo, impact factor)
Publisher Springer
Extent 357-360
Origin http://dx.doi.org/10.1007/s00784-010-0402-1
Access rights Closed access
Type Article
Web of Science ID WOS:000290313400009
URI http://repositorio.unifesp.br/handle/11600/33741

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