Psychiatric comorbidity in patients with two prototypes of focal versus generalized epilepsy syndromes

Psychiatric comorbidity in patients with two prototypes of focal versus generalized epilepsy syndromes

Author Araujo Filho, Gerardo Maria de Autor UNIFESP Google Scholar
Mazetto, Lenon Autor UNIFESP Google Scholar
Silva, Joyce Macedo da Autor UNIFESP Google Scholar
Caboclo, Luís Otávio Sales Ferreira Autor UNIFESP Google Scholar
Yacubian, Elza Márcia Targas Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract The frequency of psychiatric disorders (PD) in a homogeneous series of patients with temporal lobe epilepsy with mesial temporal sclerosis (TLE-MTS) compared to patients with juvenile myoclonic epilepsy (JME) was evaluated, aiming to determine the frequency of PD and possible differences in psychiatric diagnoses between these two epileptic syndromes. Data from 248 patients with refractory TLE-MTS and from 124 JME patients were reviewed and compared. There was a high prevalence of PD in both groups of epilepsy patients, present in 100 TLE-MTS (41%) and in 58 JME patients (46.7%). Mood (23.7%), anxiety (13.7%) and psychotic (11.6%) disorders were the most frequent diagnoses in TLE-MTS group, while mood and anxiety disorders (25% and 21%, respectively) were the most common PD among JME. Psychoses were significantly associated with TLE-MTS (p = 0.01). These observations are concordant with our previous study, reforcing the existence of a possible anatomic correlation of PD and brain structures involved in both epilepsy syndromes. (C) 2011 British Epilepsy Association. Published by Elsevier B.V. All rights reserved.
Keywords Temporal lobe epilepsy
Mesial temporal sclerosis
Juvenile myoclonic epilepsy
Psychiatric disorders
Language English
Sponsor Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Date 2011-06-01
Published in Seizure-european Journal of Epilepsy. London: W B Saunders Co Ltd, v. 20, n. 5, p. 383-386, 2011.
ISSN 1059-1311 (Sherpa/Romeo, impact factor)
Publisher W B Saunders Co Ltd
Extent 383-386
Origin http://dx.doi.org/10.1016/j.seizure.2011.01.007
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000291295600005
URI http://repositorio.unifesp.br/handle/11600/33719

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