Association of oxidative stress markers and C-reactive protein with multidimensional indexes in COPD

Association of oxidative stress markers and C-reactive protein with multidimensional indexes in COPD

Author Folchini, F. Autor UNIFESP Google Scholar
Nonato, N. L. Autor UNIFESP Google Scholar
Feofiloff, E. Autor UNIFESP Google Scholar
D'Almeida, V. Autor UNIFESP Google Scholar
Nascimento, O. Autor UNIFESP Google Scholar
Jardim, J. R. Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract To evaluate the oxidative stress and the C-reactive protein (CRP) in chronic obstructive pulmonary disease (COPD) patients and their correlation between the severity of the disease according to GOLD criteria and multidimensional indexes such as BODE index. A blood sample was collected for thiobarbituric acid reactive substances (TBARS), superoxide dismutase (SOD), catalase, glutathione (GSH), homocysteine (HCY) and CRP analysis from 45 stable COPD patients. Lung function, body nutritional status, dyspnea and 6-min walk test (6MWT) were evaluated. Patients with GOLD stage IV presented a higher value for the TBARS than stage I patients (4.47 + 1.58 versus 2.27 + 1.04 nmol/mL, p < 0.05). CRP was higher for GOLD IV (2.46 + 3.68 mg/dL) than other stages (GOLD I: 0.39 + 0.25, GOLD II: 0.39 + 0.18 and GOLD III: 0.48 + 0.36 mg/dL, p < 0.05). Oxidative stress markers measured as TBARS presented a negative correlation between forced expiratory volume in the first second (FEV1) post bronchodilatador (% predicted; r = -0.39, p = 0.01) and positive correlations with Modified Medical Research Council Scale (MMRC) dyspnea index (r = 0.40, p = 0.01), multidimensional index (r = 0.49, p = 0.001) and BODE index (r = 0.51, p = 0.001).
Keywords COPD
oxidative stress
pathophysiology
C-reactive protein
multidimensional index
Language English
Date 2011-05-01
Published in Chronic Respiratory Disease. London: Sage Publications Ltd, v. 8, n. 2, p. 101-108, 2011.
ISSN 1479-9723 (Sherpa/Romeo, impact factor)
Publisher Sage Publications Ltd
Extent 101-108
Origin http://dx.doi.org/10.1177/1479972310391284
Access rights Closed access
Type Article
Web of Science ID WOS:000208621200003
URI http://repositorio.unifesp.br/handle/11600/33692

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