Candidate-Gene Approach in Posttraumatic Stress Disorder After Urban Violence: Association Analysis of the Genes Encoding Serotonin Transporter, Dopamine Transporter, and BDNF

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dc.contributor.author Marques Valente, Nina Leao [UNIFESP]
dc.contributor.author Vallada, Homero
dc.contributor.author Cordeiro, Quirino
dc.contributor.author Miguita, Karen
dc.contributor.author Bressan, Rodrigo Affonseca [UNIFESP]
dc.contributor.author Andreoli, Sergio Baxter [UNIFESP]
dc.contributor.author Mari, Jair Jesus [UNIFESP]
dc.contributor.author Mello, Marcelo Feijo [UNIFESP]
dc.date.accessioned 2016-01-24T14:16:42Z
dc.date.available 2016-01-24T14:16:42Z
dc.date.issued 2011-05-01
dc.identifier http://dx.doi.org/10.1007/s12031-011-9513-7
dc.identifier.citation Journal of Molecular Neuroscience. Totowa: Humana Press Inc, v. 44, n. 1, p. 59-67, 2011.
dc.identifier.issn 0895-8696
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/33672
dc.description.abstract Posttraumatic stress disorder (PTSD) is a prevalent, disabling anxiety disorder marked by behavioral and physiologic alterations which commonly follows a chronic course. Exposure to a traumatic event constitutes a necessary, but not sufficient, factor. There is evidence from twin studies supporting a significant genetic predisposition to PTSD. However, the precise genetic loci still remain unclear. the objective of the present study was to identify, in a case-control study, whether the brain-derived neurotrophic factor (BDNF) val66met polymorphism (rs6265), the dopamine transporter (DAT1) three prime untranslated region (3'UTR) variable number of tandem repeats (VNTR), and the serotonin transporter (5-HTTPRL) short/long variants are associated with the development of PTSD in a group of victims of urban violence. All polymorphisms were genotyped in 65 PTSD patients as well as in 34 victims of violence without PTSD and in a community control group (n = 335). We did not find a statistical significant difference between the BDNF val66met and 5-HTTPRL polymorphism and the traumatic phenotype. However, a statistical association was found between DAT1 3'UTR VNTR nine repeats and PTSD (OR = 1.82; 95% CI, 1.20-2.76). This preliminary result confirms previous reports supporting a susceptibility role for allele 9 and PTSD. en
dc.description.sponsorship Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorship Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent 59-67
dc.language.iso eng
dc.publisher Humana Press Inc
dc.relation.ispartof Journal of Molecular Neuroscience
dc.rights Acesso restrito
dc.subject Polymorphism en
dc.subject DAT1 en
dc.subject BDNF en
dc.subject 5-HTTLPR en
dc.subject Posttraumatic stress disorder en
dc.subject PTSD en
dc.subject Violence en
dc.title Candidate-Gene Approach in Posttraumatic Stress Disorder After Urban Violence: Association Analysis of the Genes Encoding Serotonin Transporter, Dopamine Transporter, and BDNF en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Universidade de São Paulo (USP)
dc.contributor.institution Kings Coll London
dc.contributor.institution Adolfo Lutz Inst
dc.description.affiliation Universidade Federal de São Paulo, Dept Psiquiatria, BR-04023061 São Paulo, Brazil
dc.description.affiliation Univ São Paulo, Fac Med, Dept Psiquiatria & LIM 23, São Paulo, Brazil
dc.description.affiliation Kings Coll London, Hlth Serv, London WC2R 2LS, England
dc.description.affiliation Kings Coll London, Populat Res Dept, Inst Psychiat, London WC2R 2LS, England
dc.description.affiliation Adolfo Lutz Inst, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Psiquiatria, BR-04023061 São Paulo, Brazil
dc.description.sponsorshipID FAPESP: 2004/15039-0
dc.identifier.doi 10.1007/s12031-011-9513-7
dc.description.source Web of Science
dc.identifier.wos WOS:000289530900010



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