Candidate-Gene Approach in Posttraumatic Stress Disorder After Urban Violence: Association Analysis of the Genes Encoding Serotonin Transporter, Dopamine Transporter, and BDNF

Candidate-Gene Approach in Posttraumatic Stress Disorder After Urban Violence: Association Analysis of the Genes Encoding Serotonin Transporter, Dopamine Transporter, and BDNF

Author Marques Valente, Nina Leao Autor UNIFESP Google Scholar
Vallada, Homero Google Scholar
Cordeiro, Quirino Google Scholar
Miguita, Karen Google Scholar
Bressan, Rodrigo Affonseca Autor UNIFESP Google Scholar
Andreoli, Sergio Baxter Autor UNIFESP Google Scholar
Mari, Jair Jesus Autor UNIFESP Google Scholar
Mello, Marcelo Feijo Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Kings Coll London
Adolfo Lutz Inst
Abstract Posttraumatic stress disorder (PTSD) is a prevalent, disabling anxiety disorder marked by behavioral and physiologic alterations which commonly follows a chronic course. Exposure to a traumatic event constitutes a necessary, but not sufficient, factor. There is evidence from twin studies supporting a significant genetic predisposition to PTSD. However, the precise genetic loci still remain unclear. the objective of the present study was to identify, in a case-control study, whether the brain-derived neurotrophic factor (BDNF) val66met polymorphism (rs6265), the dopamine transporter (DAT1) three prime untranslated region (3'UTR) variable number of tandem repeats (VNTR), and the serotonin transporter (5-HTTPRL) short/long variants are associated with the development of PTSD in a group of victims of urban violence. All polymorphisms were genotyped in 65 PTSD patients as well as in 34 victims of violence without PTSD and in a community control group (n = 335). We did not find a statistical significant difference between the BDNF val66met and 5-HTTPRL polymorphism and the traumatic phenotype. However, a statistical association was found between DAT1 3'UTR VNTR nine repeats and PTSD (OR = 1.82; 95% CI, 1.20-2.76). This preliminary result confirms previous reports supporting a susceptibility role for allele 9 and PTSD.
Keywords Polymorphism
DAT1
BDNF
5-HTTLPR
Posttraumatic stress disorder
PTSD
Violence
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Grant number FAPESP: 2004/15039-0
Date 2011-05-01
Published in Journal of Molecular Neuroscience. Totowa: Humana Press Inc, v. 44, n. 1, p. 59-67, 2011.
ISSN 0895-8696 (Sherpa/Romeo, impact factor)
Publisher Humana Press Inc
Extent 59-67
Origin http://dx.doi.org/10.1007/s12031-011-9513-7
Access rights Closed access
Type Article
Web of Science ID WOS:000289530900010
URI http://repositorio.unifesp.br/handle/11600/33672

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