Unrelated Donor Bone Marrow Transplantation for Myelodysplastic Syndrome in Children

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dc.contributor.author Woodard, Paul
dc.contributor.author Carpenter, Paul A.
dc.contributor.author Davies, Stella M.
dc.contributor.author Gross, Thomas G.
dc.contributor.author He, Wensheng
dc.contributor.author Zhang, Mei-Jie
dc.contributor.author Horn, Biljana N.
dc.contributor.author Margolis, David A.
dc.contributor.author Perentesis, John P.
dc.contributor.author Sanders, Jean E.
dc.contributor.author Schultz, Kirk R.
dc.contributor.author Seber, Adriana [UNIFESP]
dc.contributor.author Woods, William G.
dc.contributor.author Eapen, Mary
dc.date.accessioned 2016-01-24T14:06:25Z
dc.date.available 2016-01-24T14:06:25Z
dc.date.issued 2011-05-01
dc.identifier http://dx.doi.org/10.1016/j.bbmt.2010.08.016
dc.identifier.citation Biology of Blood and Marrow Transplantation. New York: Elsevier B.V., v. 17, n. 5, p. 723-728, 2011.
dc.identifier.issn 1083-8791
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/33644
dc.description.abstract We describe long-term disease-free survival (DFS) after unrelated donor bone marrow transplantation (BMT) for myelodysplastic syndrome (MDS) in <= 8 patients aged years. Forty-six patients had refractory cytopenia (RC), 55 refractory anemia with excess blasts (RAEB), and 17 refractory anemia with excess blasts in transformation (RAEB-t). Transplant-related mortality was higher after mismatched BMT (relative risk [RR] 3.29, P=.002). Disease recurrence was more likely with advanced stages of MDS at the time of BMT: RAEB (RR 6.50, P=.01) or RAEB-t (RR 11.00, P=.004). Treatment failure (recurrent disease or death from any cause; inverse of DFS) occurred in 68 patients. Treatment failure was higher after mismatched BMT (RR 2.79, P=.001) and in those with RAEB-t (RR 2.38, P=.02). Secondary MDS or chemotherapy prior to BMT was not associated with recurrence or treatment failure. Similarly, cytogenetic abnormalities were not associated with transplant outcomes. Eight-year DFS for patients with RC after matched and mismatched unrelated donor BMT was 65% and 40%, respectively. Corresponding DFS for patients with RAEB and RAEB-t was 48% and 28%, respectively. When a matched adult unrelated donor is available, BMT should be offered as first-line therapy, and children with RC can be expected to have the best outcome. Biol Blood Marrow Transplant 17: 723-728 (2011) (C) 2011 American Society for Blood and Marrow Transplantation en
dc.description.sponsorship Public Health Service from National Cancer Institute (NCI)
dc.description.sponsorship National Heart, Lung and Blood Institute (NHLBI)
dc.description.sponsorship National Institute of Allergy and Infectious Diseases (NIAID)
dc.description.sponsorship NHLBI
dc.description.sponsorship NCI
dc.description.sponsorship Health Resources and Services Administration (HRSA/DHHS)
dc.description.sponsorship Office of Naval Research
dc.description.sponsorship AABB
dc.description.sponsorship Aetna
dc.description.sponsorship American Society for Blood and Marrow Transplantation
dc.description.sponsorship Amgen, Inc.
dc.description.sponsorship Astellas Pharma US, Inc.
dc.description.sponsorship Baxter International, Inc.
dc.description.sponsorship Bayer HealthCare Pharmaceuticals
dc.description.sponsorship Be the Match Foundation
dc.description.sponsorship Biogen IDEC
dc.description.sponsorship BioMarin Pharmaceutical, Inc.
dc.description.sponsorship Biovitrum AB
dc.description.sponsorship BloodCenter of Wisconsin
dc.description.sponsorship Blue Cross and Blue Shield Association
dc.description.sponsorship Bone Marrow Foundation
dc.description.sponsorship Buchanan Family Foundation
dc.description.sponsorship Canadian Blood and Marrow Transplant Group
dc.description.sponsorship CaridianBCT
dc.description.sponsorship Celgene Corporation
dc.description.sponsorship CellGenix, GmbH
dc.description.sponsorship Centers for Disease Control and Prevention
dc.description.sponsorship Children's Leukemia Research Association
dc.description.sponsorship ClinImmune Labs
dc.description.sponsorship CTI Clinical Trial and Consulting Services
dc.description.sponsorship Cubist Pharmaceuticals
dc.description.sponsorship Cylex Inc.
dc.description.sponsorship CytoTherm
dc.description.sponsorship DOR BioPharma, Inc.
dc.description.sponsorship Dynal Biotech, an Invitrogen Company
dc.description.sponsorship Eisai, Inc.
dc.description.sponsorship Enzon Pharmaceuticals, Inc.
dc.description.sponsorship European Group for Blood and Marrow Transplantation
dc.description.sponsorship Gamida Cell, Ltd.
dc.description.sponsorship GE Healthcare
dc.description.sponsorship Genentech, Inc.
dc.description.sponsorship Genzyme Corporation
dc.description.sponsorship Histogenetics, Inc.
dc.description.sponsorship HKS Medical Information Systems
dc.description.sponsorship Hospira, Inc.
dc.description.sponsorship Infectious Diseases Society of America
dc.description.sponsorship Kiadis Pharma
dc.description.sponsorship Kirin Brewery Co., Ltd.
dc.description.sponsorship The Leukemia & Lymphoma Society
dc.description.sponsorship Merck Company
dc.description.sponsorship Medical College of Wisconsin
dc.description.sponsorship MGI Pharma, Inc.
dc.description.sponsorship Michigan Community Blood Centers
dc.description.sponsorship Millennium Pharmaceuticals, Inc.
dc.description.sponsorship Miller Pharmacal Group
dc.description.sponsorship Milliman USA, Inc.
dc.description.sponsorship Miltenyi Biotec, Inc.
dc.description.sponsorship National Marrow Donor Program
dc.description.sponsorship Nature Publishing Group
dc.description.sponsorship New York Blood Center
dc.description.sponsorship Novartis Oncology
dc.description.sponsorship Oncology Nursing Society
dc.description.sponsorship Osiris Therapeutics, Inc.
dc.description.sponsorship Otsuka America Pharmaceutical, Inc.
dc.description.sponsorship Pall Life Sciences
dc.description.sponsorship Pfizer Inc
dc.description.sponsorship Saladax Biomedical, Inc.
dc.description.sponsorship Schering Corporation
dc.description.sponsorship Society for Healthcare Epidemiology of America
dc.description.sponsorship Soligenix, Inc.
dc.description.sponsorship StemCyte, Inc.
dc.description.sponsorship StemSoft Software, Inc
dc.description.sponsorship Sysmex America, Inc.
dc.description.sponsorship THERAKOS, Inc.
dc.description.sponsorship Thermogenesis Corporation
dc.description.sponsorship Vidacare Corporation
dc.description.sponsorship Vion Pharmaceuticals, Inc
dc.description.sponsorship ViraCor Laboratories
dc.description.sponsorship ViroPharma, Inc.
dc.description.sponsorship Well-point, Inc.
dc.format.extent 723-728
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof Biology of Blood and Marrow Transplantation
dc.rights Acesso aberto
dc.subject Pediatric myelodysplastic syndrome en
dc.subject Unrelated donor en
dc.subject Bone marrow transplantation en
dc.title Unrelated Donor Bone Marrow Transplantation for Myelodysplastic Syndrome in Children en
dc.type Artigo
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution Med Coll Wisconsin
dc.contributor.institution Amgen Inc
dc.contributor.institution Fred Hutchinson Canc Res Ctr
dc.contributor.institution Cincinnati Childrens Hosp
dc.contributor.institution Nationwide Childrens Hosp
dc.contributor.institution Univ Calif San Francisco
dc.contributor.institution Childrens Hosp Wisconsin
dc.contributor.institution UBC
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Aflac Canc Ctr & Blood Disorders Serv
dc.description.affiliation Med Coll Wisconsin, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA
dc.description.affiliation Amgen Inc, Thousand Oaks, CA USA
dc.description.affiliation Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA
dc.description.affiliation Cincinnati Childrens Hosp, Med Ctr, Cincinnati, OH USA
dc.description.affiliation Nationwide Childrens Hosp, Columbus, OH USA
dc.description.affiliation Univ Calif San Francisco, Med Ctr, San Francisco, CA 94143 USA
dc.description.affiliation Childrens Hosp Wisconsin, Milwaukee, WI 53201 USA
dc.description.affiliation UBC, British Columbia Childrens Hosp, Vancouver, BC, Canada
dc.description.affiliation Inst Oncol Pediat, São Paulo, Brazil
dc.description.affiliation Aflac Canc Ctr & Blood Disorders Serv, Childrens Healthcare Atlanta Egleston, Atlanta, GA USA
dc.description.sponsorshipID Public Health Service from National Cancer Institute (NCI): U24-CA76518
dc.description.sponsorshipID NHLBI: 5U01HL069294
dc.description.sponsorshipID Health Resources and Services Administration (HRSA/DHHS): HHSH234200637015C
dc.description.sponsorshipID Office of Naval Research: N00014-06-1-0704
dc.description.sponsorshipID Office of Naval Research: N00014-08-1-0058
dc.identifier.file WOS000290061500016.pdf
dc.identifier.doi 10.1016/j.bbmt.2010.08.016
dc.description.source Web of Science
dc.identifier.wos WOS:000290061500016



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