P-Glycoprotein Expression, Tumor Weight, Age, and Relapse in Patients with Stage I and II Favorable-Histology Wilms' Tumor

P-Glycoprotein Expression, Tumor Weight, Age, and Relapse in Patients with Stage I and II Favorable-Histology Wilms' Tumor

Author Plaza Teixeira, Roberto Augusto Google Scholar
Odone-Filho, Vicente Google Scholar
Camargo, Beatriz de Google Scholar
Zerbini, Maria Claudia Google Scholar
Fillipi, Renne Google Scholar
Alencar, Arlaine Google Scholar
Cristofani, Lilian Google Scholar
Institution Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Abstract Fifteen percent of patients with Wilms'' tumor (WT) experience relapse. It has been suggested that weight and age may affect the chances of relapse. Few studies have investigated the role, if any, between P-glycoprotein (P-gp) and relapse. the authors assessed the prognostic value of tumor weight and age at diagnosis and asked whether some other potential biological markers, specifically P-gp protein expression, had a prognostic value in favorable-histology WT. No association between age and relapse could be found. Patients with tumor weight >= a parts per thousand yen550 g were 6 times more likely to relapse, whereas P-gp expression was positive in 18/40 (45%%) of the patients, of which 10/12 (83.3%%) relapsed and 8/28 (28.6%%) did not. Further studies are necessary to elucidate whether or not P-gp is related to relapse in patients with histologically favorable Wilms'' tumor. If confirmed, the protein may be used in the future as a target for new drugs and treatments for this group of patients.</.
Keywords P-glycoprotein
prognosis
recurrence
tumor weight
Wilms' tumor
Language English
Date 2011-04-01
Published in Pediatric Hematology and Oncology. London: Informa Healthcare, v. 28, n. 3, p. 194-202, 2011.
ISSN 0888-0018 (Sherpa/Romeo, impact factor)
Publisher Informa Healthcare
Extent 194-202
Origin http://dx.doi.org/10.3109/08880018.2010.533250
Access rights Closed access
Type Article
Web of Science ID WOS:000288076400004
URI http://repositorio.unifesp.br/handle/11600/33629

Show full item record




File

File Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Search


Browse

Statistics

My Account