Melatonin administration after pilocarpine-induced status epilepticus: A new way to prevent or attenuate postlesion epilepsy?

Show simple item record

dc.contributor.author Lima, Eliangela
dc.contributor.author Cabral, Francisco R.
dc.contributor.author Cavalheiro, Esper A.
dc.contributor.author Naffah-Mazzacoratti, Maria da Graca [UNIFESP]
dc.contributor.author Amado, Debora [UNIFESP]
dc.date.accessioned 2016-01-24T14:06:22Z
dc.date.available 2016-01-24T14:06:22Z
dc.date.issued 2011-04-01
dc.identifier http://dx.doi.org/10.1016/j.yebeh.2011.01.018
dc.identifier.citation Epilepsy & Behavior. San Diego: Academic Press Inc Elsevier Science, v. 20, n. 4, p. 607-612, 2011.
dc.identifier.issn 1525-5050
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/33605
dc.description.abstract Objective: the goal of this study was to verify the effects of treatment with melatonin and N-acetylserotonin on the pilocarpine-induced epilepsy model.Methods: the animals were divided into four groups: (1) animals treated with saline (Saline); (2) animals that received pilocarpine and exhibited SE (SE); (3) animals that exhibited SE and were treated with N-acetylserotonin (30 minutes and 1, 2, 4, 6, 12, 24, 36, and 48 hours) alter SE onset (SE + NAS); (4) animals that exhibited SE and were treated with melatonin at the same time the SE + NAS group (SE + MEL). Behavioral (latency to first seizure, frequency of seizures, and mortality) and histological (Nissl and neo-Timm) parameters were analyzed.Results: the animals treated with melatonin (SE + MEL) had a decreased number of spontaneous seizures during the chronic period (P<0.05), a reduction in mossy fiber sprouting, and less cell damage than the SE group. Animals treated with N-acetylserotonin did not exhibit any kind of significant change.Conclusion: Melatonin exerts an important neuroprotective effect by attenuating SE-induced postlesion and promoting a decrease in the number of seizures in epileptic rats. This suggests, for the first time, that melatonin could be used co-therapeutically in treatment of patients exhibiting SE to minimize associated injuries in these situations. (C) 2011 Published by Elsevier Inc. en
dc.description.sponsorship Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorship Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorship Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorship CInAPCe
dc.format.extent 607-612
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof Epilepsy & Behavior
dc.rights Acesso restrito
dc.subject Epilepsy en
dc.subject Melatonin en
dc.subject N-acetylserotonin en
dc.subject Status epilepticus en
dc.subject Neuroprotection en
dc.subject Experimental model en
dc.subject Pilocarpine en
dc.title Melatonin administration after pilocarpine-induced status epilepticus: A new way to prevent or attenuate postlesion epilepsy? en
dc.type Artigo
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Hosp Israelita Albert Einstein
dc.description.affiliation Universidade Federal de São Paulo, Disciplina Neurol Expt, Escola Paulista Med, UNIFESP EPM, BR-04023900 São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Disciplina Bioquim, Escola Paulista Med, BR-04023900 São Paulo, Brazil
dc.description.affiliation Hosp Israelita Albert Einstein, Inst Cerebro, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Disciplina Neurol Expt, Escola Paulista Med, UNIFESP EPM, BR-04023900 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Disciplina Bioquim, Escola Paulista Med, BR-04023900 São Paulo, Brazil
dc.identifier.doi 10.1016/j.yebeh.2011.01.018
dc.description.source Web of Science
dc.identifier.wos WOS:000290056200004



File

File Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

Search


Browse

Statistics

My Account