Severe osteopenia and osteoporosis, sarcopenia, and frailty status in community-dwelling older women: Results from the Women's Health and Aging Study (WHAS) II

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dc.contributor.author Frisoli, Alberto [UNIFESP]
dc.contributor.author Chaves, Paulo Henrique
dc.contributor.author McNeill Ingham, Sheila Jean [UNIFESP]
dc.contributor.author Fried, Linda P.
dc.date.accessioned 2016-01-24T14:06:21Z
dc.date.available 2016-01-24T14:06:21Z
dc.date.issued 2011-04-01
dc.identifier http://dx.doi.org/10.1016/j.bone.2010.12.025
dc.identifier.citation Bone. New York: Elsevier B.V., v. 48, n. 4, p. 952-957, 2011.
dc.identifier.issn 8756-3282
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/33593
dc.description.abstract Objectives: the goal of this study was to examine the associations between severe osteopenia and osteoporosis and/or sarcopenia on frailty status, a major geriatric syndrome in community-dwelling older women.Design: Cross-sectional analysis.Setting: Women's Health and Aging Studies II (WHAS-II), Baltimore, Maryland.Participants and measurements: the analytic sample for this study included 250 women aged 76-86 years old who underwent DXA evaluation at round 4. Frailty was determined using validated screening criteria. Severe osteopenia was defined as BMD between -2.0 SD and -2.49 SD and osteoporosis as BMD less than -2.5 SD (lumbar spine and/or proximal femur). Sarcopenia was determined by the appendicular lean mass by height(2) (aLM/ht(2) method) and considered present when the value was less then 2 SD compared to young women.Results: Mean age of study subjects was 79.6 (+/-2.7) years. Overall prevalence of frailty was 6.8% (n = 17). Severe osteopenia/osteoporosis occurred in 42.1% (n = 7) in the frail group, 28% (n = 33) in the pre frail group and 25.2% in the robust group. Sarcopenia was present in 52.9% (n = 9) in the frail group, 42% (n = 50) in the pre frail and 41.2% (n = 47) in the robust group. Almost sixteen percent (n = 39) had severe osteopenia/osteoporosis concomitant to sarcopenia. in an adjusted logistic regression model, severe osteopenia/osteoporosis (OR: 2.1; 95% Cl: 0.68-6.6, p = 0.196) and sarcopenia (OR: 3.1; 95% Cl: 0.88-11.1; p = 0.077) were individually associated with frailty, though not statistically significant. On the other hand, the likelihood of being frail was substantially higher in the presence of these two syndromes (OR: 6.4; 95% Cl: 1.1-36.8, p = 0.037).Conclusion: These findings suggest a concomitant impact of severe osteopenia/osteoporosis plus sarcopenia in regard to frailty status in a sample of oldest old women living in the community. (C) 2010 Elsevier Inc. All rights reserved. en
dc.format.extent 952-957
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof Bone
dc.rights Acesso restrito
dc.subject Osteoporosis en
dc.subject Severe osteopenia en
dc.subject Sarcopenia en
dc.subject Frailty en
dc.title Severe osteopenia and osteoporosis, sarcopenia, and frailty status in community-dwelling older women: Results from the Women's Health and Aging Study (WHAS) II en
dc.type Artigo
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution Johns Hopkins Univ
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Columbia Univ
dc.description.affiliation Johns Hopkins Univ, Ctr Aging & Hlth, Baltimore, MD USA
dc.description.affiliation Universidade Federal de São Paulo, Div Cardiol, Cardiogeriatr Sect, São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Dept Orthopaed Surg, Phys Med & Rehabil Div, São Paulo, Brazil
dc.description.affiliation Columbia Univ, Mailman Sch Publ Hlth, New York, NY USA
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Div Cardiol, Cardiogeriatr Sect, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Orthopaed Surg, Phys Med & Rehabil Div, São Paulo, Brazil
dc.identifier.doi 10.1016/j.bone.2010.12.025
dc.description.source Web of Science
dc.identifier.wos WOS:000288920900034



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