Severe osteopenia and osteoporosis, sarcopenia, and frailty status in community-dwelling older women: Results from the Women's Health and Aging Study (WHAS) II

Severe osteopenia and osteoporosis, sarcopenia, and frailty status in community-dwelling older women: Results from the Women's Health and Aging Study (WHAS) II

Author Frisoli, Alberto Autor UNIFESP Google Scholar
Chaves, Paulo Henrique Google Scholar
McNeill Ingham, Sheila Jean Autor UNIFESP Google Scholar
Fried, Linda P. Google Scholar
Institution Johns Hopkins Univ
Universidade Federal de São Paulo (UNIFESP)
Columbia Univ
Abstract Objectives: the goal of this study was to examine the associations between severe osteopenia and osteoporosis and/or sarcopenia on frailty status, a major geriatric syndrome in community-dwelling older women.Design: Cross-sectional analysis.Setting: Women's Health and Aging Studies II (WHAS-II), Baltimore, Maryland.Participants and measurements: the analytic sample for this study included 250 women aged 76-86 years old who underwent DXA evaluation at round 4. Frailty was determined using validated screening criteria. Severe osteopenia was defined as BMD between -2.0 SD and -2.49 SD and osteoporosis as BMD less than -2.5 SD (lumbar spine and/or proximal femur). Sarcopenia was determined by the appendicular lean mass by height(2) (aLM/ht(2) method) and considered present when the value was less then 2 SD compared to young women.Results: Mean age of study subjects was 79.6 (+/-2.7) years. Overall prevalence of frailty was 6.8% (n = 17). Severe osteopenia/osteoporosis occurred in 42.1% (n = 7) in the frail group, 28% (n = 33) in the pre frail group and 25.2% in the robust group. Sarcopenia was present in 52.9% (n = 9) in the frail group, 42% (n = 50) in the pre frail and 41.2% (n = 47) in the robust group. Almost sixteen percent (n = 39) had severe osteopenia/osteoporosis concomitant to sarcopenia. in an adjusted logistic regression model, severe osteopenia/osteoporosis (OR: 2.1; 95% Cl: 0.68-6.6, p = 0.196) and sarcopenia (OR: 3.1; 95% Cl: 0.88-11.1; p = 0.077) were individually associated with frailty, though not statistically significant. On the other hand, the likelihood of being frail was substantially higher in the presence of these two syndromes (OR: 6.4; 95% Cl: 1.1-36.8, p = 0.037).Conclusion: These findings suggest a concomitant impact of severe osteopenia/osteoporosis plus sarcopenia in regard to frailty status in a sample of oldest old women living in the community. (C) 2010 Elsevier Inc. All rights reserved.
Keywords Osteoporosis
Severe osteopenia
Sarcopenia
Frailty
Language English
Date 2011-04-01
Published in Bone. New York: Elsevier B.V., v. 48, n. 4, p. 952-957, 2011.
ISSN 8756-3282 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 952-957
Origin http://dx.doi.org/10.1016/j.bone.2010.12.025
Access rights Closed access
Type Article
Web of Science ID WOS:000288920900034
URI http://repositorio.unifesp.br/handle/11600/33593

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