Parameters optimization defined by statistical analysis for cysteine-dextran radiolabeling with technetium tricarbonyl core

Parameters optimization defined by statistical analysis for cysteine-dextran radiolabeling with technetium tricarbonyl core

Author Fernandez Nunez, Eutimio Gustavo Google Scholar
Faintuch, Bluma Linkowski Google Scholar
Teodoro, Rodrigo Google Scholar
Wiecek, Danielle Pereira Google Scholar
Silva, Natanael Gomes da Google Scholar
Papadopoulos, Minas Google Scholar
Pelecanou, Maria Google Scholar
Pirmettis, Loannis Google Scholar
Oliveira Filho, Renato Santos de Autor UNIFESP Google Scholar
Duatti, Adriano Google Scholar
Pasqualini, Roberto Google Scholar
Institution Inst Energet & Nucl Res
Natl Ctr Sci Res Demokritos
Universidade Federal de São Paulo (UNIFESP)
Univ Ferrara
CIS Bio Int
Abstract The objective of this study was the development of a statistical approach for radiolabeling optimization of cysteine-dextran conjugates with Tc-99m tricarbonyl core. This strategy has been applied to the labeling of 2-propylene-S-cysteine-dextran in the attempt to prepare a new class of tracers for sentinel lymph node detection, and can be extended to other radiopharmaceuticals for different targets. the statistical routine was based on three-level factorial design. Best labeling conditions were achieved. the specific activity reached was 5 MBq/mu g. Crown Copyright (C) 2011 Published by Elsevier B.V. All rights reserved.
Keywords [(99m)Tc(OH(2))(3)(CO)(3)](+) precursor
Technetium
Radiolabeling
Experimental design
Dextran
Statistical analysis
Language English
Sponsor National Commission for Nuclear Energy (CNEN, São Paulo, Brazil)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
International Atomic Energy Agency (IAEA, Vienna, Austria)
Date 2011-04-01
Published in Applied Radiation and Isotopes. Oxford: Pergamon-Elsevier B.V., v. 69, n. 4, p. 663-669, 2011.
ISSN 0969-8043 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 663-669
Origin http://dx.doi.org/10.1016/j.apradiso.2011.01.006
Access rights Closed access
Type Article
Web of Science ID WOS:000287893700003
URI http://repositorio.unifesp.br/handle/11600/33591

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