Adolescent mice are more vulnerable than adults to single injection-induced behavioral sensitization to amphetamine

Adolescent mice are more vulnerable than adults to single injection-induced behavioral sensitization to amphetamine

Author Kameda, Sonia Regina Autor UNIFESP Google Scholar
Fukushiro, Daniela Fukue Autor UNIFESP Google Scholar
Trombin, Thaís Fernanda Autor UNIFESP Google Scholar
Procopio-Souza, Roberta Autor UNIFESP Google Scholar
Patti, Camilla de Lima Autor UNIFESP Google Scholar
Hollais, André Willian Autor UNIFESP Google Scholar
Calzavara, Mariana Bendlin Autor UNIFESP Google Scholar
Abílio, Vanessa Costhek Autor UNIFESP Google Scholar
Ribeiro, Rosana de Alencar Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
D'Almeida, Vânia Autor UNIFESP Google Scholar
Frussa Filho, Roberto Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Drug-induced behavioral sensitization in rodents has enhanced our understanding of why drugs acquire increasing motivational and incentive value. Compared to adults, human adolescents have accelerated dependence courses with shorter times from first exposure to dependence. We compared adolescent and adult mice in their ability to develop behavioral sensitization to amphetamine following a single injection. Adult (90-day-old) and adolescent (45-day-old) male Swiss mice received an acute intraperitoneal injection of saline or amphetamine (1.0. 2.0 or 4.0 mg/kg). Seven days later, half of the mice from the saline group received a second injection of saline. the remaining animals were challenged with 2.0 mg/kg amphetamine. Following all of the injections, mice were placed in activity chambers and locomotion was quantified for 45 min. the magnitude of both the acute and sensitized locomotor stimulatory effect of amphetamine was higher in the adolescent mice. Previous experience with the test environment inhibited the acute amphetamine stimulation in both adolescent and adult mice, but facilitated the detection of elevated spontaneous locomotion in adolescent animals. These results support the notion that the adolescent period is associated with an increased risk for development of drug abuse. Additionally, they indicate a complex interaction between the environmental novelty, adolescence and amphetamine. (C) 2011 Elsevier Inc. All rights reserved.
Keywords Adolescent
Adult
Amphetamine
Behavioral sensitization
Locomotion
Mice
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Fundo de Apoio ao Docente e Aluno (FADA)
Associacao Fundo de Pesquisa em Psicobiologia (AFIP)
Date 2011-04-01
Published in Pharmacology Biochemistry and Behavior. Oxford: Pergamon-Elsevier B.V., v. 98, n. 2, p. 320-324, 2011.
ISSN 0091-3057 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 320-324
Origin http://dx.doi.org/10.1016/j.pbb.2011.01.013
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000289396300024
URI http://repositorio.unifesp.br/handle/11600/33569

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