Inhibition of tumor growth by quercetin with increase of survival and prevention of cachexia in Walker 256 tumor-bearing rats

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dc.contributor.author Camargo, Camila A.
dc.contributor.author Silva, Maria Eleonora F. da
dc.contributor.author Silva, Rodrigo A. da
dc.contributor.author Justo, Giselle Z. [UNIFESP]
dc.contributor.author Gomes-Marcondes, Maria Cristina C.
dc.contributor.author Aoyama, Hiroshi
dc.date.accessioned 2016-01-24T14:06:19Z
dc.date.available 2016-01-24T14:06:19Z
dc.date.issued 2011-03-25
dc.identifier http://dx.doi.org/10.1016/j.bbrc.2011.02.111
dc.identifier.citation Biochemical and Biophysical Research Communications. San Diego: Academic Press Inc Elsevier Science, v. 406, n. 4, p. 638-642, 2011.
dc.identifier.issn 0006-291X
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/33562
dc.description.abstract Quercetin, a flavonoid abundantly present in fruit, vegetables, wine and tea, has revealed several properties such as antioxidant, antiproliferative and anticancer. Cachexia is a poorly understood syndrome present in already compromised cancer patients, decreasing the quality of life and increasing mortality. Many studies have been performed in an attempt to discover an effective treatment for cachexia, but none of the tested therapies has fulfilled expectations. the objective of the present study was to analyze the effect of quercetin in the therapeutic treatment of cachexia and reversion of tumor growth in rats bearing Walker 256 carcinosarcoma (W256). Rats bearing W256 were treated daily with I.P. quercetin injections, at different doses (10, 15, 25 and 35 mg/kg). the results show that 10 mg/kg quercetin inhibited tumor growth by about 50% (ED(50)) when compared with controls (CTR). Moreover, two animals of this group presented complete tumor regression. Matrix metalloproteinase-2 (MMP-2) activity and vascular endothelial growth factor (VEGF) expression decreased in rats bearing W256 treated with 10 mg/kg quercetin when compared with CTR. Thus, the inhibition of tumor growth, survival increase, decrease of MMP-2 and VEGF levels and reduction of cachexia in animals treated with quercetin strongly support the anticancer function of this flavonoid. (C) 2011 Elsevier Inc. All rights reserved. en
dc.description.sponsorship Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorship Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent 638-642
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof Biochemical and Biophysical Research Communications
dc.rights Acesso restrito
dc.subject Quercetin en
dc.subject Walker 256 carcinosarcoma en
dc.subject Cachexia en
dc.subject Survival en
dc.subject Cancer en
dc.title Inhibition of tumor growth by quercetin with increase of survival and prevention of cachexia in Walker 256 tumor-bearing rats en
dc.type Artigo
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution Universidade Estadual de Campinas (UNICAMP)
dc.contributor.institution Univ Paulista
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Univ Estadual Campinas, Inst Biol, Dept Bioquim, São Paulo, Brazil
dc.description.affiliation Univ Estadual Campinas, Inst Biol, Dept Anat Biol Celular & Fisiol, São Paulo, Brazil
dc.description.affiliation Univ Paulista, Inst Ciencias Saude, São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Dept Bioquim, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Bioquim, São Paulo, Brazil
dc.identifier.doi 10.1016/j.bbrc.2011.02.111
dc.description.source Web of Science
dc.identifier.wos WOS:000289036600026



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