Inhibition of tumor growth by quercetin with increase of survival and prevention of cachexia in Walker 256 tumor-bearing rats

Inhibition of tumor growth by quercetin with increase of survival and prevention of cachexia in Walker 256 tumor-bearing rats

Author Camargo, Camila A. Google Scholar
Silva, Maria Eleonora F. da Google Scholar
Silva, Rodrigo A. da Google Scholar
Justo, Giselle Z. Autor UNIFESP Google Scholar
Gomes-Marcondes, Maria Cristina C. Google Scholar
Aoyama, Hiroshi Google Scholar
Institution Universidade Estadual de Campinas (UNICAMP)
Univ Paulista
Universidade Federal de São Paulo (UNIFESP)
Abstract Quercetin, a flavonoid abundantly present in fruit, vegetables, wine and tea, has revealed several properties such as antioxidant, antiproliferative and anticancer. Cachexia is a poorly understood syndrome present in already compromised cancer patients, decreasing the quality of life and increasing mortality. Many studies have been performed in an attempt to discover an effective treatment for cachexia, but none of the tested therapies has fulfilled expectations. the objective of the present study was to analyze the effect of quercetin in the therapeutic treatment of cachexia and reversion of tumor growth in rats bearing Walker 256 carcinosarcoma (W256). Rats bearing W256 were treated daily with I.P. quercetin injections, at different doses (10, 15, 25 and 35 mg/kg). the results show that 10 mg/kg quercetin inhibited tumor growth by about 50% (ED(50)) when compared with controls (CTR). Moreover, two animals of this group presented complete tumor regression. Matrix metalloproteinase-2 (MMP-2) activity and vascular endothelial growth factor (VEGF) expression decreased in rats bearing W256 treated with 10 mg/kg quercetin when compared with CTR. Thus, the inhibition of tumor growth, survival increase, decrease of MMP-2 and VEGF levels and reduction of cachexia in animals treated with quercetin strongly support the anticancer function of this flavonoid. (C) 2011 Elsevier Inc. All rights reserved.
Keywords Quercetin
Walker 256 carcinosarcoma
Cachexia
Survival
Cancer
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Date 2011-03-25
Published in Biochemical and Biophysical Research Communications. San Diego: Academic Press Inc Elsevier Science, v. 406, n. 4, p. 638-642, 2011.
ISSN 0006-291X (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 638-642
Origin http://dx.doi.org/10.1016/j.bbrc.2011.02.111
Access rights Closed access
Type Article
Web of Science ID WOS:000289036600026
URI http://repositorio.unifesp.br/handle/11600/33562

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