Diffuse Intrinsic Brainstem Tumor in an Infant: A Case of Therapeutic Efficacy With Vinorelbine

Diffuse Intrinsic Brainstem Tumor in an Infant: A Case of Therapeutic Efficacy With Vinorelbine

Author Cappellano, Andrea Maria Autor UNIFESP Google Scholar
Bouffet, Eric Google Scholar
Cavalheiro, Sergio Autor UNIFESP Google Scholar
Seixas, Maria T. Autor UNIFESP Google Scholar
Silva, Nasjla Saba da Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Hosp Sick Children
Abstract Brainstem gliomas constitute 10% to 20% of all pediatric tumors of the central nervous system, and diffusely infiltrative brainstem gliomas are the most common brainstem tumors associated with a poor prognosis. A small subset of these tumors is benign, showing low-grade features on histology. the role of chemotherapy in the management of these tumors is ill defined, especially in the neonates. There are anecdotal reports of spontaneous remission, but the natural history of these tumors does not support a wait-and-see approach. Thus, we report a successful experience of chemotherapy in a 4-month-old girl with a diffuse brainstem fibrillary astrocytoma, treated with vinorelbine (30 mg/m(2)/d on days 0, 8, and 22), a vinca alkaloid that has shown activity against glioma. Our experience suggests that vinorelbine may be effective in pediatric low-grade gliomas as this patient showed significant clinical improvement over a short period of time.
Keywords brainstem glioma in children
neonate
vinorelbine
Language English
Date 2011-03-01
Published in Journal of Pediatric Hematology Oncology. Philadelphia: Lippincott Williams & Wilkins, v. 33, n. 2, p. 116-118, 2011.
ISSN 1077-4114 (Sherpa/Romeo, impact factor)
Publisher Lippincott Williams & Wilkins
Extent 116-118
Origin http://dx.doi.org/10.1097/MPH.0b013e3181fe68e0
Access rights Closed access
Type Article
Web of Science ID WOS:000287648800021
URI http://repositorio.unifesp.br/handle/11600/33542

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