Catechol-O-methyltransferase (COMT) val158met Polymorphism as a Risk Factor for PTSD After Urban Violence

Catechol-O-methyltransferase (COMT) val158met Polymorphism as a Risk Factor for PTSD After Urban Violence

Author Marques Valente, Nina Leao Autor UNIFESP Google Scholar
Vallada, Homero Autor UNIFESP Google Scholar
Cordeiro, Quirino Autor UNIFESP Google Scholar
Bressan, Rodrigo Affonseca Google Scholar
Andreoli, Sergio Baxter Google Scholar
Mari, Jair Jesus Google Scholar
Mello, Marcelo Feijo Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Kings Coll London
Abstract PTSD is a psychiatric disorder that requires a traumatic event as diagnostic criteria. Brazil has high rates of violence, and it is expected that urban victims of violence would be at risk to the development of PTSD. Studies have associated the COMT val158met polymorphism with diminished stress resilience, reduced ability to extinguish conditioned fear, and the development of PTSD after multiple traumatic experiences. the aim of this study was to identify, in a case-control study, whether the val158met polymorphism (rs4860) is associated with the development of PTSD in a group of victims of urban violence. To our knowledge, this is the first study that examines the association between PTSD and urban violence. the polymorphism of COMT in PTSD patients (n = 65) as well as in victims of violence without PTSD (n = 34) and in a community control group (n = 335) were genotyped. We found a significant relationship between the met allele (p < 0.02) and PTSD among cases (PTSD+)and victims of violence without PTSD (PTSD-; OR 2.57) and between cases and community control group (p < 0.003) Further analysis with larger samples and another ethnic group should be necessary to confirm our findings.
Keywords Polymorphism
COMT
Post traumatic stress disorder
PTSD
Violence
Language English
Sponsor Fundacao de Amparo a Pesquisa Estado de São Paulo
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Grant number Fundacao de Amparo a Pesquisa Estado de São Paulo: 2004/15039-0
Date 2011-03-01
Published in Journal of Molecular Neuroscience. Totowa: Humana Press Inc, v. 43, n. 3, p. 516-523, 2011.
ISSN 0895-8696 (Sherpa/Romeo, impact factor)
Publisher Humana Press Inc
Extent 516-523
Origin http://dx.doi.org/10.1007/s12031-010-9474-2
Access rights Closed access
Type Article
Web of Science ID WOS:000287503500036
URI http://repositorio.unifesp.br/handle/11600/33517

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