Role of Fos-related antigen 1 in the progression and prognosis of ductal breast carcinoma

Show simple item record Logullo, Angela Flavia [UNIFESP] Agata Stiepcich, Monica Maria Bueno de Toledo Osorio, Cintia Aparecida [UNIFESP] Nonogaki, Sueli Pasini, Fatima Solange Rocha, Rafael Malagoli Soares, Fernando Augusto Brentani, Maria M. 2016-01-24T14:06:13Z 2016-01-24T14:06:13Z 2011-03-01
dc.identifier.citation Histopathology. Malden: Wiley-Blackwell, v. 58, n. 4, p. 617-625, 2011.
dc.identifier.issn 0309-0167
dc.description.abstract Aims:Fos-related antigen 1 (Fra-1) is a member of the activator protein 1 (AP-1) transcription factor family. Our objective was to evaluate the role of Fra-1 expression in breast carcinoma progression and prognosis.Methods and results:Fra-1 expression was investigated by immunohistochemistry in two tissue microarrays containing, respectively, 85 ductal carcinoma in situ (DCIS) and 771 invasive ductal carcinoma (IDC) samples. Staining was observed in the nucleus and cytoplasm of the carcinomas, but only nuclear staining was considered to be positive. Fibroblasts associated with IDC were also Fra-1-positive. the frequency of Fra-1 positivity in IDC (22.8%) was lower than that in DCIS (42.2%). No association was found between Fra-1 and clinico-pathological variables in DCIS. in IDC, Fra-1 expression correlated with aggressive phenotype markers, including: high grade, oestrogen receptor negativity and human epidermal growth factor receptor 2 (HER-2) positivity (P = 0.001, 0.015 and 0.004, respectively), and marginally with the presence of metastasis (P = 0.07). Fra-1 was more frequently positive in basal-like (34%) and in HER-2-positive (38.5%) subtypes than in luminal subtypes. Fra-1 presence did not correlate with survival.Conclusions:A high frequency of Fra-1 in DCIS tumours may be associated with early events in breast carcinogenesis. Although Fra-1 expression correlated with features of a more aggressive phenotype in IDC, no relationship with overall survival was found. en
dc.description.sponsorship Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorship Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent 617-625
dc.language.iso eng
dc.publisher Wiley-Blackwell
dc.relation.ispartof Histopathology
dc.rights Acesso aberto
dc.subject ductal breast carcinoma en
dc.subject Fra-1 en
dc.subject prognosis en
dc.subject progression en
dc.title Role of Fos-related antigen 1 in the progression and prognosis of ductal breast carcinoma en
dc.type Artigo
dc.contributor.institution Universidade de São Paulo (USP)
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Hosp AC Camargo Fund Antonio Prudente
dc.description.affiliation Univ São Paulo, Fac Med, Dept Radiol & Oncol, Disciplina Oncol LIM24, São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Dept Patol, São Paulo, Brazil
dc.description.affiliation Hosp AC Camargo Fund Antonio Prudente, Dept Patol, São Paulo, Brazil
dc.description.affiliation Univ São Paulo, Dept Patol, Inst Adolfo Lutz, BR-09500900 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Patol, São Paulo, Brazil
dc.description.sponsorshipID FAPESP: 04/04607-8
dc.identifier.file WOS000288508800014.pdf
dc.identifier.doi 10.1111/j.1365-2559.2011.03785.x
dc.description.source Web of Science
dc.identifier.wos WOS:000288508800014


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