Role of Fos-related antigen 1 in the progression and prognosis of ductal breast carcinoma

Role of Fos-related antigen 1 in the progression and prognosis of ductal breast carcinoma

Author Logullo, Angela Flavia Autor UNIFESP Google Scholar
Agata Stiepcich, Monica Maria Google Scholar
Bueno de Toledo Osorio, Cintia Aparecida Autor UNIFESP Google Scholar
Nonogaki, Sueli Google Scholar
Pasini, Fatima Solange Google Scholar
Rocha, Rafael Malagoli Google Scholar
Soares, Fernando Augusto Google Scholar
Brentani, Maria M. Google Scholar
Institution Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Hosp AC Camargo Fund Antonio Prudente
Abstract Aims:Fos-related antigen 1 (Fra-1) is a member of the activator protein 1 (AP-1) transcription factor family. Our objective was to evaluate the role of Fra-1 expression in breast carcinoma progression and prognosis.Methods and results:Fra-1 expression was investigated by immunohistochemistry in two tissue microarrays containing, respectively, 85 ductal carcinoma in situ (DCIS) and 771 invasive ductal carcinoma (IDC) samples. Staining was observed in the nucleus and cytoplasm of the carcinomas, but only nuclear staining was considered to be positive. Fibroblasts associated with IDC were also Fra-1-positive. the frequency of Fra-1 positivity in IDC (22.8%) was lower than that in DCIS (42.2%). No association was found between Fra-1 and clinico-pathological variables in DCIS. in IDC, Fra-1 expression correlated with aggressive phenotype markers, including: high grade, oestrogen receptor negativity and human epidermal growth factor receptor 2 (HER-2) positivity (P = 0.001, 0.015 and 0.004, respectively), and marginally with the presence of metastasis (P = 0.07). Fra-1 was more frequently positive in basal-like (34%) and in HER-2-positive (38.5%) subtypes than in luminal subtypes. Fra-1 presence did not correlate with survival.Conclusions:A high frequency of Fra-1 in DCIS tumours may be associated with early events in breast carcinogenesis. Although Fra-1 expression correlated with features of a more aggressive phenotype in IDC, no relationship with overall survival was found.
Keywords ductal breast carcinoma
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Grant number FAPESP: 04/04607-8
Date 2011-03-01
Published in Histopathology. Malden: Wiley-Blackwell, v. 58, n. 4, p. 617-625, 2011.
ISSN 0309-0167 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 617-625
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000288508800014

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