Assessment of rates of structural change in glaucoma using imaging technologies

Assessment of rates of structural change in glaucoma using imaging technologies

Autor Mansouri, K. Google Scholar
Leite, Mauro Toledo Autor UNIFESP Google Scholar
Medeiros, F. A. Google Scholar
Leung, C. K. Google Scholar
Weinreb, R. N. Google Scholar
Instituição Univ Calif San Diego
Univ Geneva
Universidade Federal de São Paulo (UNIFESP)
Chinese Univ Hong Kong
Resumo Purpose To review the ability of current imaging technologies to provide estimates of rates of structural change in glaucoma patients.Patients and methods Review of literature.Results Imaging technologies, such as confocal scanning laser ophthalmoscopy (CSLO), scanning laser polarimetry (SLP), and optical coherence tomography (OCT), provide quantifiable and reproducible measurements of the optic disc and parapapillary retinal nerve fibre layer (RNFL). Rates of change as quantified by the rim area (RA) (for CSLO) and RNFL thickness (for SLP and OCT) are related to glaucoma progression as detected by conventional methods (eg, visual fields and optic disc photography). Evidence shows that rates of RNFL and RA loss are significantly faster in progressing compared with non-progressing glaucoma patients.Conclusion Measurements of rates of optic disc and RNFL change are becoming increasingly precise and individualized. Currently available imaging technologies have the ability to detect and quantify progression in glaucoma, and their measurements may be suitable end points in glaucoma clinical trials. Eye (2011) 25, 269-277; doi:10.1038/eye.2010.202; published online 7 January 2011
Assunto glaucoma
rate of change
scanning laser polarimetry
confocal scanning laser ophthalmoscopy
optical coherence tomography
imaging technology
Idioma Inglês
Financiador Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Número do financiamento CAPES: BEX1327/09-7
: NEI R01-EY08208
Data 2011-03-01
Publicado em Eye. London: Nature Publishing Group, v. 25, n. 3, p. 269-277, 2011.
ISSN 0950-222X (Sherpa/Romeo, fator de impacto)
Editor Nature Publishing Group
Extensão 269-277
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000288240500002

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