Differential sympathetic activation induced by intermittent hypoxia and sleep loss in rats: Action of angiotensin (1-7)

Differential sympathetic activation induced by intermittent hypoxia and sleep loss in rats: Action of angiotensin (1-7)

Autor Perry, Juliana Cini Autor UNIFESP Google Scholar
Bergamaschi, Cassia oledo Autor UNIFESP Google Scholar
Campos, Ruy Ribeiro Autor UNIFESP Google Scholar
Andersen, Monica Levy Autor UNIFESP Google Scholar
Casarini, Dulce Elena Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo The present study attempted to evaluate the effects of chronic intermittent hypoxia (CIH) associated with sleep restriction in hemodynamic parameters and the plasma renin-angiotensin system. Wistar-Hannover rats were submitted to isolated CIH exposure (1000-1600 h), sleep restriction (1600-1000 h), defined as 18-h paradoxical sleep deprivation followed by 6-h sleep permission period and CIH associated to sleep restriction for 21 days. the CIH and sleep restriction group showed a preferential increase in renal sympathetic nervous system (rSNA) associated with a reduction in plasma angiotensin (1-7) concentrations. However, CIH-sleep restriction rats did not modify rSNA and showed a higher angiotensin (1-7) concentration when compared to isolated CIH and sleep restriction. These results suggest that CIH and sleep restriction impaired the cardiovascular system, and its association to sleep loss can modify these effects by partially restoring circulating angiotensin (1-7). (C) 2010 Elsevier B.V. All rights reserved.
Assunto Hypoxia
Sleep restriction
Sympathetic activity
Renin-angiotensin system
Angiotensin 1-7
Idioma Inglês
Financiador Associacao Fundo de lncentivo a Psicofarmacologia (AFIP)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Número do financiamento FAPESP: 98/14303-3
CNPq: 558924/2008-5
Data 2011-02-24
Publicado em Autonomic Neuroscience-basic & Clinical. Amsterdam: Elsevier B.V., v. 160, n. 1-2, p. 32-36, 2011.
ISSN 1566-0702 (Sherpa/Romeo, fator de impacto)
Editor Elsevier B.V.
Extensão 32-36
Fonte http://dx.doi.org/10.1016/j.autneu.2010.11.006
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000287989000006
URI http://repositorio.unifesp.br/handle/11600/33473

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