N-Acetyltransferase 2 genetic polymorphisms and risk of colorectal cancer

N-Acetyltransferase 2 genetic polymorphisms and risk of colorectal cancer

Author Silva, Tiago Donizetti da Autor UNIFESP Google Scholar
Felipe, Aledson Vitor Autor UNIFESP Google Scholar
Lima, Jacqueline Miranda de Autor UNIFESP Google Scholar
Oshima, Celina Tizuko Fujiyama Autor UNIFESP Google Scholar
Forones, Nora Manoukian Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract AIM: To investigate the possible association between meat intake, cigarette smoking and N-acetyltransferase 2 (NAT2) genetic polymorphisms on colorectal cancer (CRC) risk.METHODS: Patients with CRC were matched for gender and age to healthy controls. Meat intake and cigarette smoking were assessed using a specific frequency questionnaire. DNA was extracted from peripheral blood and the genotypes of the polymorphism were assessed by polymerase chain reaction-restriction fragment length polymorphism. Five NAT2 alleles were studied (WT, M1, M2, M3 and M4) using specific digestion enzymes.RESULTS: A total of 147 patients with colorectal cancer (76 women and 90 men with colon cancer) and 212 controls were studied. the mean age of the two groups was 62 years. More than half the subjects (59.8% in the case group and 51.9% in the control group) were NAT2 slow acetylators. the odds ratio for colorectal cancer was 1.38 (95% CI: 0.90-2.12) in slow acetylators. Although the number of women was small (n = 76 in the case group), the cancer risk was found to be lower in intermediate (W/Mx) acetylators [odds ratio (OR): 0.55, 95% confidence interval (95% CI): 0.29-1.02]. This difference was not observed in men (OR: 0.56, 95% CI: 0.16-2.00). Among NAT2 fast acetylators (W/W or W/Mx), meat consumption more than 3 times a week increased the risk of colorectal cancer (OR: 2.05, 95% CI: 1.01-4.16). in contrast, cigarette smoking increased the risk of CRC among slow acetylators (OR: 1.97, 95% CI: 1.02-3.79).CONCLUSION: the risk of CRC was higher among fast acetylators who reported a higher meat intake. Slow NAT2 acetylation was associated with an increased risk of CRC. (C) 2011 Baishideng. All rights reserved.
Keywords N-acetyltransferase 2
Polymorphism
Colorectal cancer
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Date 2011-02-14
Published in World Journal of Gastroenterology. Beijing: Baishideng Publ Grp Co Ltd, v. 17, n. 6, p. 760-765, 2011.
ISSN 1007-9327 (Sherpa/Romeo, impact factor)
Publisher Baishideng Publ Grp Co Ltd
Extent 760-765
Origin http://dx.doi.org/10.3748/wjg.v17.i6.760
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000288058700010
URI http://repositorio.unifesp.br/handle/11600/33465

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