Short Communication: Intermediate Prevalence of HIV Type 1 Primary Antiretroviral Resistance in Ceara State, Northeast Brazil

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dc.contributor.author Arruda, Erico
dc.contributor.author Simoes, Leda
dc.contributor.author Sucupira, Maria Cecilia [UNIFESP]
dc.contributor.author Medeiros, Melissa [UNIFESP]
dc.contributor.author Arruda, Eurico
dc.contributor.author Diaz, Ricardo S. [UNIFESP]
dc.contributor.author Lima, Aldo
dc.date.accessioned 2016-01-24T14:06:09Z
dc.date.available 2016-01-24T14:06:09Z
dc.date.issued 2011-02-01
dc.identifier http://dx.doi.org/10.1089/aid.2010.0028
dc.identifier.citation Aids Research and Human Retroviruses. New Rochelle: Mary Ann Liebert Inc, v. 27, n. 2, p. 153-156, 2011.
dc.identifier.issn 0889-2229
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/33430
dc.description.abstract Brazil is a large developing country where almost all FDA-licensed antiretrovirals are made available to almost 200,000 individuals under antiretroviral treatment. General primary HIV-1 resistance in Brazil is assumed to be low, but data are scarce, especially in the Northeast region. To evaluate the prevalence of primary HIV-1 antiretroviral resistance in the state of Ceara, Brazil, a cross-sectional prospective study of antiretroviral-naive HIV-1-infected individuals was performed between May 2008 and May 2009. Genomic sequences of reverse transcriptase and protease regions of the pol gene of HIV-1 using PCR products were obtained. Mutations related to resistance to NRTI, NNRTI, and PI were evaluated according to the WHO mutation list for primary resistance surveillance, which excludes common polymorphisms. Seventy-four individuals were evaluated (50% male) with a median age 30 years; 55.4% were men who have sex with men. Median CD4(+) T lymphocyte counts were 418 and 960 cells/mm(3) and the median viral loads were 4.41 and 4.46 log(10) RNA copies/ml for individuals older and younger that 18 years, respectively. Twenty-seven percent of patients were symptomatic. Five patients (6.8%) were recently infected, as detected by the BED test. the mutations 41L, 67N, 215D, 219Q, 101E, and 103N in the RT and 321, 461, 54V, 82T, and 90M, in the PR were identified in 9.5% of samples, more frequently in HIV subtype B (85.1%). A significant level of primary HIV resistance was detected in urban Northeast Brazil, a region geographically distant from the more highly populated and wealthier areas of Southeast Brazil, and this emphasizes the need for monitoring resistance in the studied area. en
dc.format.extent 153-156
dc.language.iso eng
dc.publisher Mary Ann Liebert Inc
dc.relation.ispartof Aids Research and Human Retroviruses
dc.rights Acesso restrito
dc.title Short Communication: Intermediate Prevalence of HIV Type 1 Primary Antiretroviral Resistance in Ceara State, Northeast Brazil en
dc.type Artigo
dc.contributor.institution Hosp Sao Jose Doencas Infecciosas
dc.contributor.institution Lab Cent Estado
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Ctr Especialidades Med Jose de Alencar
dc.contributor.institution Fac Med Ribeirao Preto
dc.contributor.institution Univ Fed Ceara
dc.contributor.institution Unidade Pesquisa Cin
dc.contributor.institution Inst Biomed
dc.description.affiliation Hosp Sao Jose Doencas Infecciosas, Fortaleza, Ceara, Brazil
dc.description.affiliation Lab Cent Estado, Fortaleza, Ceara, Brazil
dc.description.affiliation Univ Fed Estado São Paulo, Escola Paulista Med, Lab Retrovirol, São Paulo, Brazil
dc.description.affiliation Ctr Especialidades Med Jose de Alencar, Fortaleza, Ceara, Brazil
dc.description.affiliation Fac Med Ribeirao Preto, Virol Lab, São Paulo, Brazil
dc.description.affiliation Univ Fed Ceara, Fac Med, Fortaleza, Ceara, Brazil
dc.description.affiliation Unidade Pesquisa Cin, Fortaleza, Ceara, Brazil
dc.description.affiliation Inst Biomed, Fortaleza, Ceara, Brazil
dc.description.affiliationUnifesp Univ Fed Estado São Paulo, Escola Paulista Med, Lab Retrovirol, São Paulo, Brazil
dc.identifier.doi 10.1089/aid.2010.0028
dc.description.source Web of Science
dc.identifier.wos WOS:000287006200008



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