Specific effects of reactive thiol drugs on mitochondrial bioenergetics

Specific effects of reactive thiol drugs on mitochondrial bioenergetics

Author Nantes, Iseli L. Google Scholar
Rodrigues, Tiago Google Scholar
Caires, Antonio C. F. Google Scholar
Cunha, Rodrigo L. O. R. Google Scholar
Pessoto, Felipe S. Autor UNIFESP Google Scholar
Yokomizo, Cesar H. Google Scholar
Araujo-Chaves, Juliana C. Google Scholar
Faria, Priscila A. Google Scholar
Santana, Debora P. Google Scholar
Santos, Carolina G. dos Google Scholar
Institution Universidade Federal do ABC (UFABC)
Univ Mogi das Cruzes
Universidade Federal de São Paulo (UNIFESP)
Abstract In this minireview, the more recent findings about the effects of peculiar reactive thiol drugs on mitochondria are presented. These include the following compounds: metallo meso-tetrakis porphyrins, palladacycles, telluranes and phenothiazines. Metallo meso-tetrakis porphyrins can exhibit both beneficial and deleterious effects on mitochodria that are modulated by the central metal, cell location, and availability of axial ligands. Therefore, these compounds have the versatility to be used for cell and mitochondria protection and death. the antioxidant activity of manganese porphyrins is related to a glutathione peroxidase-like activity. By attacking exclusively the membrane protein thiol groups without glutathione depletion, palladacycles are able to induce mitochondrial permeability transition (MPT) and cytochrome c release in the absence of oxidative stress. in hepatoma cells, the mitochondrial action of palladacycles was able to induce apoptotic death. As opposed to palladacycles, telluranes and phenothiazines are able to conjugate the capacity to promote the MPT in a dose-dependent manner in association with efficient antioxidant activity toward lipids. These studies demonstrated that the action of drugs on mitochondrial bioenergetics can be modulated by peculiar reactivity with thiol groups. Therefore, they contribute to studies of toxicity as well as the design of new drugs.
Keywords Thiol reactivity
Mitochondrial permeability transition
Language English
Date 2011-02-01
Published in Journal of Bioenergetics and Biomembranes. New York: Springer/plenum Publishers, v. 43, n. 1, p. 11-18, 2011.
ISSN 0145-479X (Sherpa/Romeo, impact factor)
Publisher Springer
Extent 11-18
Origin http://dx.doi.org/10.1007/s10863-011-9328-9
Access rights Closed access
Type Article
Web of Science ID WOS:000287970700003
URI http://repositorio.unifesp.br/handle/11600/33407

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