Genetic Variation among Major Human Geographic Groups Supports a Peculiar Evolutionary Trend in PAX9

Show simple item record Paixao-Cortes, Vanessa R. Meyer, Diogo Pereira, Tiago da Veiga [UNIFESP] Mazieres, Stephane Elion, Jacques Krishnamoorthy, Rajagopal Zago, Marco A. Silva, Wilson A. Salzano, Francisco M. Bortolini, Maria Catira 2016-01-24T14:06:04Z 2016-01-24T14:06:04Z 2011-01-27
dc.identifier.citation Plos One. San Francisco: Public Library Science, v. 6, n. 1, 7 p., 2011.
dc.identifier.issn 1932-6203
dc.description.abstract A total of 172 persons from nine South Amerindian, three African and one Eskimo populations were studied in relation to the Paired box gene 9 (PAX9) exon 3 (138 base pairs) as well as its 5' and 3' flanking intronic segments (232 bp and 220 bp, respectively) and integrated with the information available for the same genetic region from individuals of different geographical origins. Nine mutations were scored in exon 3 and six in its flanking regions; four of them are new South American tribe-specific singletons. Exon3 nucleotide diversity is several orders of magnitude higher than its intronic regions. Additionally, a set of variants in the PAX9 and 101 other genes related with dentition can define at least some dental morphological differences between Sub-Saharan Africans and non-Africans, probably associated with adaptations after the modern human exodus from Africa. Exon 3 of PAX9 could be a good molecular example of how evolvability works. en
dc.description.sponsorship Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorship Institutos do Milenio and Programa de Apoio a Nucleos de Excelencia Programs
dc.description.sponsorship Fundacao de Amparo a Pesquisa do Estado do Rio Grande do Sul
dc.description.sponsorship Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent 7
dc.language.iso eng
dc.publisher Public Library Science
dc.relation.ispartof Plos One
dc.rights Acesso aberto
dc.title Genetic Variation among Major Human Geographic Groups Supports a Peculiar Evolutionary Trend in PAX9 en
dc.type Artigo
dc.contributor.institution Univ Fed Rio Grande do Sul
dc.contributor.institution Universidade de São Paulo (USP)
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution CNRS
dc.contributor.institution Fac Med
dc.contributor.institution Univ Paris Diderot
dc.description.affiliation Univ Fed Rio Grande do Sul, Inst Biociencias, Dept Genet, BR-90049 Porto Alegre, RS, Brazil
dc.description.affiliation Univ São Paulo, Inst Biociencias, Dept Genet & Biol Evolut, São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Dept Bioquim, São Paulo, Brazil
dc.description.affiliation CNRS, Lab Anthropobiol, FRE2960, Toulouse, France
dc.description.affiliation Fac Med, CS80011, Marseille, France
dc.description.affiliation Univ Paris Diderot, Hop Robert Debre, Insern, UMR 763, Paris, France
dc.description.affiliation Univ São Paulo, Fac Med, Dept Clin Med, São Paulo, Brazil
dc.description.affiliation Univ São Paulo, Fac Med Ribeirao Preto, Dept Genet, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Bioquim, São Paulo, Brazil
dc.identifier.file WOS000286663900016.pdf
dc.identifier.doi 10.1371/journal.pone.0015656
dc.description.source Web of Science
dc.identifier.wos WOS:000286663900016


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