Genetic Variation among Major Human Geographic Groups Supports a Peculiar Evolutionary Trend in PAX9

Genetic Variation among Major Human Geographic Groups Supports a Peculiar Evolutionary Trend in PAX9

Autor Paixao-Cortes, Vanessa R. Google Scholar
Meyer, Diogo Google Scholar
Pereira, Tiago da Veiga Autor UNIFESP Google Scholar
Mazieres, Stephane Google Scholar
Elion, Jacques Google Scholar
Krishnamoorthy, Rajagopal Google Scholar
Zago, Marco A. Google Scholar
Silva, Wilson A. Google Scholar
Salzano, Francisco M. Google Scholar
Bortolini, Maria Catira Google Scholar
Instituição Univ Fed Rio Grande do Sul
Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
CNRS
Fac Med
Univ Paris Diderot
Resumo A total of 172 persons from nine South Amerindian, three African and one Eskimo populations were studied in relation to the Paired box gene 9 (PAX9) exon 3 (138 base pairs) as well as its 5' and 3' flanking intronic segments (232 bp and 220 bp, respectively) and integrated with the information available for the same genetic region from individuals of different geographical origins. Nine mutations were scored in exon 3 and six in its flanking regions; four of them are new South American tribe-specific singletons. Exon3 nucleotide diversity is several orders of magnitude higher than its intronic regions. Additionally, a set of variants in the PAX9 and 101 other genes related with dentition can define at least some dental morphological differences between Sub-Saharan Africans and non-Africans, probably associated with adaptations after the modern human exodus from Africa. Exon 3 of PAX9 could be a good molecular example of how evolvability works.
Idioma Inglês
Financiador Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Institutos do Milenio and Programa de Apoio a Nucleos de Excelencia Programs
Fundacao de Amparo a Pesquisa do Estado do Rio Grande do Sul
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Data 2011-01-27
Publicado em Plos One. San Francisco: Public Library Science, v. 6, n. 1, 7 p., 2011.
ISSN 1932-6203 (Sherpa/Romeo, fator de impacto)
Editor Public Library Science
Extensão 7
Fonte http://dx.doi.org/10.1371/journal.pone.0015656
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000286663900016
URI http://repositorio.unifesp.br/handle/11600/33362

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