Does acute swimming exercise alter the bioavailability of the radiopharmaceutical technetium-99m methylenediphosphonate (Tc-99m-MDP) in Wistar rats?

Does acute swimming exercise alter the bioavailability of the radiopharmaceutical technetium-99m methylenediphosphonate (Tc-99m-MDP) in Wistar rats?

Author Souza, Deise E. Google Scholar
Pereira, Marcia O. Google Scholar
Brito, Lavinia C. Google Scholar
Souza, Raphael S. S. Google Scholar
Almeida, Marcela C. Google Scholar
Fonseca, Adenilson S. Google Scholar
Santos-Filho, Sebastiao D. Google Scholar
Vaisberg, Mauro Autor UNIFESP Google Scholar
Bernardo-Filho, Mario Google Scholar
Institution Universidade do Estado do Rio de Janeiro (UERJ)
Universidade Federal de São Paulo (UNIFESP)
Inst Nacl Canc
Abstract Experimental models have aided to understand the mechanism and the exercise effects on biological systems. To evaluate the effects of acute swimming exercise on the bioavailability of the radiopharmaceutical technetium-99m methylenediphosphonate (Tc-99m-MDP) used for bone scintigraphy, the rats were divided into control, sedentary, and exercised groups. Sedentary and exercised groups were adapted to water for 2 weeks (5 min/day, 5 days/week). After that, the exercised groups (EG) were submitted to acute swimming exercise for 5, 10 or 20 min (loads of 5% of body weight), and then all animals were anaesthetized, Tc-99m-MDP was administered and after 180 min the animals were sacrificed. Blood and organs were removed, the radioactivity was determined in a well counter and the percentage per gram of tissue of injected dose (% ID/g) was calculated. the findings showed a significant decrease of % ID/g in the hearts of the sedentary group, EG-5min, EG-10min and EG-20min when compared to the control group, in the bones of EG-20min when compared to the control group, and in the lungs of EG-5min and EG-10min when compared to the control group. These findings could be associated with specific modifications of the metabolism in certain organs, which are highly relevant when evaluations of the bone using Tc-99m-MDP are being carried out. (C) Koninklijke Brill NV, Leiden, 2011.
Keywords Biodistribution
radiopharmaceutical
effect
animal
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ)
Universidade do Estado do Rio de Janeiro (UERJ)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Grant number FAPERJ: E-16/2009
Date 2011-01-01
Published in Animal Biology. Leiden: Brill Academic Publishers, v. 61, n. 4, p. 403-412, 2011.
ISSN 1570-7555 (Sherpa/Romeo, impact factor)
Publisher Brill Academic Publishers
Extent 403-412
Origin http://dx.doi.org/10.1163/157075511X596882
Access rights Closed access
Type Article
Web of Science ID WOS:000298161400004
URI http://repositorio.unifesp.br/handle/11600/33339

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