Malnutrition in Infancy as a Susceptibility Factor for Temporal Lobe Epilepsy in Adulthood Induced by the Pilocarpine Experimental Model

Malnutrition in Infancy as a Susceptibility Factor for Temporal Lobe Epilepsy in Adulthood Induced by the Pilocarpine Experimental Model

Author Cabral, Francisco Romero Autor UNIFESP Google Scholar
Priel, Margareth Rose Google Scholar
Silva Araujo, Bruno Henrique Autor UNIFESP Google Scholar
Torres, Laila Brito Autor UNIFESP Google Scholar
Lima, Eliangela de Autor UNIFESP Google Scholar
Vale, Tiago Gurgel do Autor UNIFESP Google Scholar
Pereira, Felipe Autor UNIFESP Google Scholar
Amorim, Henrique Alves de Autor UNIFESP Google Scholar
Cavalheiro, Esper Abrao Autor UNIFESP Google Scholar
Scerni, Debora Amado Autor UNIFESP Google Scholar
Naffah-Mazzacoratti, Maria da Graca Autor UNIFESP Google Scholar
Institution Inst Israelita Ensino Pesquisa Albert Einstein
Universidade Federal de São Paulo (UNIFESP)
Ctr Univ Sao Camilo
Ctr Nacl Primatas
Abstract Malnutrition during the earliest stages of life may result in innumerable brain problems. Moreover, this condition could increase the chances of developing neurological diseases, such as epilepsy. We analyzed the effects of early-life malnutrition on susceptibility to epileptic seizures induced by the pilocarpine model of epilepsy. Wistar rat pups were kept on a starvation regimen from day 1 to day 21 after birth. At day 60, 16 animals (8 = well-nourished; 8 = malnourished) were exposed to the pilocarpine experimental model of epilepsy. Age-matched well-nourished (n = 8) and malnourished (n = 8) rats were used as controls. Animals were video-monitored over 9 weeks. the following behavioral parameters were evaluated: first seizure threshold (acute period of the pilocarpine model); status epilepticus (SE) latency; first spontaneous seizure latency (silent period), and spontaneous seizure frequency during the chronic phase. the cell and mossy fiber sprouting (MFS) density were evaluated in the hippocampal formation. Our results showed that the malnourished animals required a lower pilocarpine dose in order to develop SE (200 mg/kg), lower latency to reach SE, less time for the first spontaneous seizure and higher seizure frequency, when compared to well-nourished pilocarpine rats. Histopathological findings revealed a significant cell density reduction in the CA1 region and intense MFS among the malnourished animals. Our data indicate that early malnutrition greatly influences susceptibility to seizures and behavioral manifestations in adult life. These findings suggest that malnutrition in infancy reduces the threshold for epilepsy and promotes alterations in the brain that persist into adult life. Copyright (C) 2011 S. Karger AG, Basel
Keywords Epilepsy
Brain development
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Date 2011-01-01
Published in Developmental Neuroscience. Basel: Karger, v. 33, n. 6, p. 469-478, 2011.
ISSN 0378-5866 (Sherpa/Romeo, impact factor)
Publisher Karger
Extent 469-478
Access rights Closed access
Type Article
Web of Science ID WOS:000301888600001

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