Lovastatin decreases the synthesis of inflammatory mediators in the hippocampus and blocks the hyperthermia of rats submitted to long-lasting status epilepticus

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dc.contributor.author Furtado Gouveia, Telma Luciana [UNIFESP]
dc.contributor.author Scorza, Fulvio Alexandre [UNIFESP]
dc.contributor.author Vieira Silva, Michele Juliana [UNIFESP]
dc.contributor.author Bandeira, Tatiane de Aquino [UNIFESP]
dc.contributor.author Perosa, Sandra Regina [UNIFESP]
dc.contributor.author Arganaraz, Gustavo Adolfo [UNIFESP]
dc.contributor.author Silva, Marcelo de Paula [UNIFESP]
dc.contributor.author Araujo, Thiago Rodrigues [UNIFESP]
dc.contributor.author Berzaghi Frangiotti, Maria Isabel [UNIFESP]
dc.contributor.author Amado, Debora [UNIFESP]
dc.contributor.author Cavalheiro, Esper Abrao [UNIFESP]
dc.contributor.author Silva, Jose Antonio
dc.contributor.author Naffah-Mazzacoratti, Maria da Graca [UNIFESP]
dc.date.accessioned 2016-01-24T14:05:59Z
dc.date.available 2016-01-24T14:05:59Z
dc.date.issued 2011-01-01
dc.identifier http://dx.doi.org/10.1016/j.yebeh.2010.10.001
dc.identifier.citation Epilepsy & Behavior. San Diego: Academic Press Inc Elsevier Science, v. 20, n. 1, p. 1-5, 2011.
dc.identifier.issn 1525-5050
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/33295
dc.description.abstract Statins may act on inflammatory responses, decreasing oxidative stress and also reducing temperature after a brain ischemic insult. Previous data have indicated that statins protect neurons from death during long-lasting status epilepticus (SE) and attenuate seizure behaviors in animals treated with kainic acid. in this context, the study described here aimed to investigate the effect of lovastatin on body temperature and on mRNA expression levels of hippocampal cytokines such as interleukin-1 beta, interleukin-6, tumor necrosis factor a, and kinin B1 and B2 receptors of rats submitted to pilocarpine-induced SE. Quantitative real-time polymerase chain reaction showed a significant decrease in mRNA expression of interleukin-1 beta, interleukin-6, tumor necrosis factor a, and kinin B1 receptor in animals with SE treated with lovastatin, compared with untreated animals with SE (P<0.001). Lovastatin also reduced SE-induced hyperthermia, indicating that mechanisms related to brain protection are triggered by this drug under conditions associated with acute excitotoxicity or long-lasting SE. (c) 2010 Elsevier Inc. All rights reserved. en
dc.description.sponsorship Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorship Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorship CinAPCe
dc.format.extent 1-5
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof Epilepsy & Behavior
dc.rights Acesso restrito
dc.subject Lovastatin en
dc.subject Inflammatory mediators en
dc.subject Hippocampus en
dc.subject Temporal lobe epilepsy en
dc.subject Neuroprotection en
dc.title Lovastatin decreases the synthesis of inflammatory mediators in the hippocampus and blocks the hyperthermia of rats submitted to long-lasting status epilepticus en
dc.type Artigo
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Univ Nove Julho
dc.contributor.institution Univ Fed Rio Grande do Norte
dc.description.affiliation Universidade Federal de São Paulo, Dept Neurol & Neurocirurg, BR-862 Botucatu, SP, Brazil
dc.description.affiliation Univ Nove Julho, São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Dept Bioquim, São Paulo, Brazil
dc.description.affiliation Univ Fed Rio Grande do Norte, BR-59072970 Natal, RN, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Neurol & Neurocirurg, BR-862 Botucatu, SP, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Bioquim, São Paulo, Brazil
dc.identifier.doi 10.1016/j.yebeh.2010.10.001
dc.description.source Web of Science
dc.identifier.wos WOS:000287331300001



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