Polymorphisms in VEGF, progesterone receptor and IL-1 receptor genes in women with recurrent spontaneous abortion

Polymorphisms in VEGF, progesterone receptor and IL-1 receptor genes in women with recurrent spontaneous abortion

Author Traina, Evelyn Autor UNIFESP Google Scholar
Daher, Silvia Autor UNIFESP Google Scholar
Moron, Antonio Fernandes Autor UNIFESP Google Scholar
Sun, Sue Yazaki Autor UNIFESP Google Scholar
Franchim, Camila Sommerauer Autor UNIFESP Google Scholar
Mattar, Rosiane Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Hormonal, inflammatory and vascular alterations during pregnancy are thought to be involved in pregnancy loss. the role of progesterone, the actions of which involve cytokines and vascular endothelial growth factor (VEGF), has been thoroughly studied. Genetic factors are involved in modulation of these molecules, and several genes have been associated with recurrent spontaneous abortion (RSA), as well other obstetric conditions. Here we investigate the relationship between RSA and gene polymorphisms of the progesterone receptor (PROGINS), interleukin-1 receptor 1 (PstI) and vascular endothelial growth factor (VEGF) (-634, 936). This case-controlled study comprised a total of 89 women with idiopathic RSA and a control group of 191 women with at least two successful pregnancies and no miscarriages. Genomic DNA was extracted from whole blood, and polymorphism genotyping was conducted by digesting PCR products with specific restriction endonucleases. No correlations were found in any of the investigated polymorphisms, even among dominant, co-dominant and additive inheritance models and alleles. Our results support the hypothesis that these specific gene polymorphisms are not the major determinant of pregnancy success. Although we did not find any correlations, the investigation of these and other polymorphisms remains a challenge in the evaluation of RSA. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
Keywords Habitual abortion
Polymorphism
Progesterone receptors
VEGF
Interleukin-1
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Grant number FAPESP: 06/56312-7
Date 2011-01-01
Published in Journal of Reproductive Immunology. Clare: Elsevier B.V., v. 88, n. 1, p. 53-57, 2011.
ISSN 0165-0378 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 53-57
Origin http://dx.doi.org/10.1016/j.jri.2010.07.006
Access rights Closed access
Type Article
Web of Science ID WOS:000286540100008
URI http://repositorio.unifesp.br/handle/11600/33281

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