White adipose tissue re-growth after partial lipectomy in high fat diet induced obese Wistar rats

White adipose tissue re-growth after partial lipectomy in high fat diet induced obese Wistar rats

Author Bueno, Allain Amador Google Scholar
Habitante, Carlos Alexandre Google Scholar
Oyama, Lila Missae Autor UNIFESP Google Scholar
Estadella, Debora Autor UNIFESP Google Scholar
Ribeiro, Eliane Beraldi Autor UNIFESP Google Scholar
Oller do Nascimento, Claudia Maria Autor UNIFESP Google Scholar
Institution London Metropolitan Univ
Univ Fed de Mato Grosso
Universidade Federal de São Paulo (UNIFESP)
Abstract The effects of partial removal of epididymal (EPI) and retroperitoneal (RET) adipose tissues (partial lipectomy) on the triacylglycerol deposition of high fat diet induced obese rats were analyzed, aiming to challenge the hypothesized body fat regulatory system. Male 28-day-old wistar rats received a diet enriched with peanuts, milk chocolate and sweet biscuits during the experimental period. At the 90th day of life, rats were submitted to either lipectomy (L) or sham surgery. After 7 or 30 days, RET, EPI, liver, brown adipose tissue (BAT), blood and carcass were obtained and analyzed. Seven days following surgery, liver lipogenesis rate and EPI relative weight were increased in L. After 30 days, L, RET and EPI presented increased lipogenesis, lipolysis and percentage of small area adipocytes. L rats also presented increased liver malic enzyme activity, BAT lipogenesis, and triacylglycerol and corticosterone serum levels. the partial removal of visceral fat pads affected the metabolism of high fat diet obese rats, which leads to excised tissue regrowth and possibly compensatory growth of non-excised depots at a later time.
Keywords Partial lipectomy
High fat diet
Obesity
Adipose tissue
Triacylglycerol deposition
Language English
Sponsor Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Date 2011-01-01
Published in Journal of Physiological Sciences. Tokyo: Springer Tokyo, v. 61, n. 1, p. 55-63, 2011.
ISSN 1880-6546 (Sherpa/Romeo, impact factor)
Publisher Springer
Extent 55-63
Origin http://dx.doi.org/10.1007/s12576-010-0122-y
Access rights Closed access
Type Article
Web of Science ID WOS:000289858400007
URI http://repositorio.unifesp.br/handle/11600/33266

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