Prevalence of pneumococcal serotypes and resistance to antimicrobial agents in patients with meningitis: ten-year analysis

Prevalence of pneumococcal serotypes and resistance to antimicrobial agents in patients with meningitis: ten-year analysis

Author Alvares, Jackelline Rodrigues Google Scholar
Mantese, Orlando Cesar Google Scholar
Paula, Alan de Google Scholar
Wolkers, Paula Carolina Bejo Google Scholar
Almeida, Viviene Vieira Prado Google Scholar
Almeida, Samanta Cristine Grassi Autor UNIFESP Google Scholar
Guerra, Maria Luiza Leopoldo Silva Google Scholar
Brandileone, Maria Cristina de Cunto Autor UNIFESP Google Scholar
Institution Med Sch Uberlandia
Universidade Federal de Uberlândia (UFU)
Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Inst Adolfo Lutz Registro
Abstract Objectives: To determine the prevalence of pneumococcal serotypes and antimicrobial susceptibility in patients with meningitis, and to evaluate the implications for vaccine coverage. Methods: Pneumococcal strains obtained from normally sterile fluids from patients admitted with meningitis were isolated at the Hospital de Clinicas of the Universidade Federal de Uberlandia, Minas Gerais State, and sent to the Instituto Adolfo Lutz, city of São Paulo, São Paulo State, for further identification, serotyping, and antimicrobial susceptibility determination. Results: From April 1999 to April 2009, 338 pneumococcal strains were isolated, and 72 obtained from patients with meningitis, were analyzed. Patients' ages varied from one month to 82.2 years (mean of 18.4 +/- 22.9 years; median of 5.2 years) and 46 (63.9%) patients were male. Strains were isolated from cerebrospinal fluid [66 occasions (91.7%)] and blood [6 occasions (8.3%)]. the most commonly identified serotypes were 14, 19F, 3, 7F, 6A, 6B, 10A, 18C, 23F, 5, and 34. of the 20 [27.8%] oxacillin-resistant strains, 17 [23.6%] were resistant to penicillin and nine [12.5%] to ceftriaxone, both resistance patterns being more common in children aged two years or less and during the 2005-2009 period. Conclusions: Resistance to penicillin and ceftriaxone was detected in 23.6% and 12.5% of the strains, respectively, and predominated in children aged two years or less and during the 2005-2009 period. There were 24 different serotypes of pneumococcus and 79.8% of the serotypes were represented in the 7-valent conjugated vaccine [PVC7].
Keywords Streptococcus pneumoniae
meningitis
serotyping
pneumococcal vaccines
drug resistance
Language English
Date 2011-01-01
Published in Brazilian Journal of Infectious Diseases. Salvador: Contexto, v. 15, n. 1, p. 22-27, 2011.
ISSN 1413-8670 (Sherpa/Romeo, impact factor)
Publisher Contexto
Extent 22-27
Origin http://dx.doi.org/10.1590/S1413-86702011000100005
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000288385100005
SciELO ID S1413-86702011000100005 (statistics in SciELO)
URI http://repositorio.unifesp.br/handle/11600/33221

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