Defining the Molecular Basis of Tumor Metabolism: a Continuing Challenge Since Warburg's Discovery

Defining the Molecular Basis of Tumor Metabolism: a Continuing Challenge Since Warburg's Discovery

Author Santos de Souza, Ana Carolina Google Scholar
Justo, Giselle Zenker Autor UNIFESP Google Scholar
Araujo, Daniele Ribeiro de Google Scholar
Cavagis, Alexandre D. Martins Google Scholar
Institution Universidade Federal do ABC (UFABC)
Universidade Federal de São Paulo (UNIFESP)
Universidade Federal de São Carlos (UFSCar)
Abstract Cancer cells are the product of genetic disorders that alter crucial intracellular signaling pathways associated with the regulation of cell survival, proliferation, differentiation and death mechanisms. the role of oncogene activation and tumor suppressor inhibition in the onset of cancer is well established. Traditional antitumor therapies target specific molecules, the action/expression of which is altered in cancer cells. However, since the physiology of normal cells involves the same signaling pathways that are disturbed in cancer cells, targeted therapies have to deal with side effects and multidrug resistance, the main causes of therapy failure. Since the pioneering work of Otto Warburg, over 80 years ago, the subversion of normal metabolism displayed by cancer cells has been highlighted by many studies. Recently, the study of tumor metabolism has received much attention because metabolic transformation is a crucial cancer hallmark and a direct consequence of disturbances in the activities of oncogenes and tumor suppressors. in this review we discuss tumor metabolism from the molecular perspective of oncogenes, tumor suppressors and protein signaling pathways relevant to metabolic transformation and tumorigenesis. We also identify the principal unanswered questions surrounding this issue and the attempts to relate these to their potential for future cancer treatment. As will be made clear, tumor metabolism is still only partly understood and the metabolic aspects of transformation constitute a major challenge for science. Nevertheless, cancer metabolism can be exploited to devise novel avenues for the rational treatment of this disease. Copyright (C) 2011 S. Karger AG, Basel
Keywords Tumor metabolism
Tumor suppressors
Warburg effect
Antitumor therapies
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Grant number FAPESP: 10/16050-9
FAPESP: 10/11475-1
FAPESP: 08/51116-0
Date 2011-01-01
Published in Cellular Physiology and Biochemistry. Basel: Karger, v. 28, n. 5, p. 771-792, 2011.
ISSN 1015-8987 (Sherpa/Romeo, impact factor)
Publisher Karger
Extent 771-792
Access rights Open access Open Access
Type Review
Web of Science ID WOS:000298488600001

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