Parasite and egg burden, hepatic collagen and histologic pattern of liver granulomas in selection III high and low antibody responder mice infected with Schistosoma mansoni

Parasite and egg burden, hepatic collagen and histologic pattern of liver granulomas in selection III high and low antibody responder mice infected with Schistosoma mansoni

Autor Catapani, Wilson Roberto Google Scholar
Parise, Edison Roberto Autor UNIFESP Google Scholar
Leite-Mór, Marilisa Moraes Barros Autor UNIFESP Google Scholar
Sadigursky, M. Google Scholar
Andrade, Z. A. Google Scholar
Sant'Anna, O. A. Google Scholar
Miszputen, Sender Jankiel Autor UNIFESP Google Scholar
Siqueira, M. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
FIOCRUZ Centro de Pesquisas Gonçalo Muniz
Instituto Butantan Laboratório de Imunogenética
Resumo Selection III mice have particular immunological characteristics: they are high (H III) or low (L III) antibody producer animals, yet both lines display similar T cell responses and macrophage activities. We submittedthese mice to infection with Schistosoma mansoni to assess in vivo parasite and egg burden, hepatic collagen and cellular composition of granulomas in both lines. Titration of anti-Schistosoma IgG by ELISA showed remarkably higher values inH III line, at both studied periods (8th and 12th weeks post-infection). Nevertheless, the number of adult worms recovered from the portal system was similar inboth lines, being not associated with anti-Schistosoma antibody levels. There isan increase in hepatic collagen from the 8th to the 12th weeks post-infection, which is paralleled by an increase in the number of eggs in the liver. This association apparently occurs at the same radio in H III and L III animals. The most important difference found between the two lines was the outstanding contrast interms of volume and eosinophil counts in the granulomas, with lesions from H IIImice clearly being larger and containing more of these cells than LIII lesions.
Palavra-chave Schistosoma mansoni
collagen
granulomas
schistosomiasis
hight and low antibody mice
Idioma Inglês
Data de publicação 1994-03-01
Publicado em Memórias do Instituto Oswaldo Cruz. Instituto Oswaldo Cruz, Ministério da Saúde, v. 89, n. 1, p. 63-67, 1994.
ISSN 0074-0276 (Sherpa/Romeo, fator de impacto)
Publicador Instituto Oswaldo Cruz, Ministério da Saúde
Extensão 63-67
Fonte http://dx.doi.org/10.1590/S0074-02761994000100012
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:A1994NW66100012
SciELO S0074-02761994000100012 (estatísticas na SciELO)
Endereço permanente http://repositorio.unifesp.br/handle/11600/332

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