Change in central kinin B2 receptor density after exercise training in rats

Change in central kinin B2 receptor density after exercise training in rats

Author Caetano, Ariadiny Lima Google Scholar
Viel, Tania Araujo Google Scholar
Queiroz Prado Bittencourt, Maria Fernanda Google Scholar
Araujo, Mariana Silva Autor UNIFESP Google Scholar
De Angelis, Katia Google Scholar
Buck, Hudson Sousa Google Scholar
Institution Fac Ciencias Med Santa Casa São Paulo
Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Univ Sao Judas Tadeu
Abstract Cardiovascular responses elicited by the stimulation of kinin B2 receptors in the IV cerebral ventricle paratrigeminal nucleus or in the thoracic spinal cord are similar to those observed during an exercise bout Considering that the kalikrein-kinin system (KKS) could act on the cardiovascular modulation during behavioral responses as physical exercise or stress this study evaluated the central B2 receptor densities of Wistar (W) and spontani ously hypertensive rats (SHR) after chronic moderate exercise Animals we re exercise-trained for ten weeks on a treadmill Afterwards systolic blood pressure decreased in both trained strains Animals were killed and the medulla and spinal cord extracted for B2 receptor autoradiography Trained animals were compared to their sedentary controls Sedentary groups showed specific binding sites for Hoe-140 (fmol/mg of tissue) in laminas 1 and 2 of the spinal cord nucleus of the solitary tract (NTS) area postrema (AP) spinal trigeminal tract (sp5) and paratrigeminal nucleus (Pa5) in trained W a significant increase (p<0 05) in specific binding was observed in the Pa5 (31 3%) and NTS (28 2%) Trained SHR showed a significant decrease in n ceptor density in lamina 2 (21 9%) of the thoracic spinal cord and an increase in specific binding in Pa5 (36 1%) We suggest that in the medulla chronic exercise could hyper stimulate the KKS enhancing their efficiency through the increase of B2 receptor density involving this receptor in central cardiovascular control during exercise or stress in the lamina 2 B2 receptor might be involved in the exercise-induced hypotension (C) 2010 Elsevier BV All rights reserved
Keywords Bradykinin
Blood pressure
Kinin receptors
Language English
Sponsor Fundo de Amparo a Pesquisa de Faculdade de Ciencias Medicas da Santa Casa de São Paulo
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Grant number FAPESP: 2007/04800-0
Date 2010-12-08
Published in Autonomic Neuroscience-basic & Clinical. Amsterdam: Elsevier B.V., v. 158, n. 1-2, p. 71-78, 2010.
ISSN 1566-0702 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 71-78
Access rights Closed access
Type Article
Web of Science ID WOS:000284926900012

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