Exercise Training Reduces PGE(2) Levels and Induces Recovery from Steatosis in Tumor-bearing Rats

Exercise Training Reduces PGE(2) Levels and Induces Recovery from Steatosis in Tumor-bearing Rats

Author Lira, F. S. Autor UNIFESP Google Scholar
Yamashita, A. S. Google Scholar
Carnevali, L. C. Google Scholar
Goncalves, D. C. Google Scholar
Lima, W. P. Google Scholar
Rosa, J. C. Autor UNIFESP Google Scholar
Caperuto, E. C. Google Scholar
Rosa, L. F. C. Google Scholar
Seelaender, M. Google Scholar
Institution Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Abstract The effects of endurance training on PGE(2) levels and upon the maximal activity of hepatic carnitine palmitoyltransferase (CPT) system were studied in rats bearing the Walker 256 carciosarcoma. Animals were randomly assigned to a sedentary control (SC), sedentary tumor-bearing (ST), exercised control (EC), and as an exercised tumor-bearing (ET) group. Trained rats ran on a treadmill (60% VO2 max) for 60 min/day, 5 days/week, for 8 weeks. We examined the mRNA expression (RT-PCR) and maximal activity (radio-assay) of the carnitine palmitoyltransferase system enzymes (CPT I and CPT II), as well as the gene expression of fatty-acid-binding protein (L-FABP) in the liver. PGE(2) content was measured in the serum, in tumor cells, and in the liver (ELISA). CPT I and CPT II maximal activity were decreased (p < 0.01) in ST when compared with SC. in contrast, serum PGE(2) was increased (p < 0.05) in cachectic animals as compared with SC. in the liver, PGE(2) content was also increased (p < 0.05) when compared with SC. Endurance training restored maximal CPT I and CPT II activity in the tumor-bearing animals (p < 0.0001). Exercise training induced PGE(2) levels to return to control values in the liver of tumor-bearing training rats (p < 0.05) and decreased the eicosanoid content in the tumor (p < 0.01). in conclusion, endurance training was capable of reestablishing liver carnitine palmitoyltransferase (CPT) system activity associated with decreased PGE(2) levels in cachectic tumor-bearing animals, preventing steatosis.
Keywords cachexia
exercise training
CPT system
PGE(2) levels
Language English
Date 2010-12-01
Published in Journal of Rare Earths. Amsterdam: Elsevier B.V., v. 28, n. 6, p. 944-U263, 2010.
ISSN 1002-0721 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 944-U263
Origin http://dx.doi.org/10.1055/s-0030-1267949
Access rights Closed access
Type Article
Web of Science ID WOS:000284944000025
URI http://repositorio.unifesp.br/handle/11600/33142

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