The role of the Hoxa10/HOXA10 gene in the etiology of endometriosis and its related infertility: a review

The role of the Hoxa10/HOXA10 gene in the etiology of endometriosis and its related infertility: a review

Author Zanatta, Alysson Google Scholar
Rocha, Andre M. Google Scholar
Carvalho, Filomena M. Google Scholar
Pereira, Ricardo M. A. Google Scholar
Taylor, Hugh S. Google Scholar
Motta, Eduardo L. A. Autor UNIFESP Google Scholar
Baracat, Edmund C. Google Scholar
Serafini, Paulo C. Google Scholar
Institution Huntington Med Reprod
Universidade de São Paulo (USP)
Yale Univ
Universidade Federal de São Paulo (UNIFESP)
Abstract Endometriosis and its associated infertility have been the object of continuous research for over a century. To understand the molecular mechanisms underlying the disease, it has become necessary to determine the aspects of its etiology that are not explained by the retrograde menstruation theory. This could in turn elucidate how various clinical and surgical treatments might affect the evolution and remission of the disease.This review is focused on the most recent clinical and laboratory findings regarding the association of HOXA10 with endometriosis and infertility.The homebox (Hox/HOX) proteins are highly conserved transcription factors that determine segmental body identities in multiple species, including humans. Hoxa10/HOXA10 is directly involved in the embryogenesis of the uterus and embryo implantation via regulation of downstream genes. Cyclical endometrial expression of Hoxa10/HOXA10, with a peak of expression occurring during the window of implantation, is observed in the adult in response to estrogen and progesterone. Women with endometriosis do not demonstrate the expected mid-luteal rise of HOXA10 expression, which might partially explain the infertility observed in many of these patients. Recent studies also demonstrated HOXA10 expression in endometriotic foci outside the Mullerian tract.Multiple lines of evidence suggest that the actions of the homeobox A10 (Hoxa10/HOXA10) gene could account for some aspects of endometriosis.
Keywords Homeobox genes
Hoxa10
Endometriosis
Etiology
Infertility
Surgery
Language English
Date 2010-12-01
Published in Journal of Assisted Reproduction and Genetics. New York: Springer/plenum Publishers, v. 27, n. 12, p. 701-710, 2010.
ISSN 1058-0468 (Sherpa/Romeo, impact factor)
Publisher Springer
Extent 701-710
Origin http://dx.doi.org/10.1007/s10815-010-9471-y
Access rights Closed access
Type Article
Web of Science ID WOS:000285098700006
URI http://repositorio.unifesp.br/handle/11600/33116

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