Bone marrow cell therapy prevents infarct expansion and improves border zone remodeling after coronary occlusion in rats

Show simple item record

dc.contributor.author Santos, Leonardo dos [UNIFESP]
dc.contributor.author Santos, Alexandra A. [UNIFESP]
dc.contributor.author Goncalves, Giovana A.
dc.contributor.author Krieger, Jose Eduardo
dc.contributor.author Ferreira Tucci, Paulo Jose [UNIFESP]
dc.date.accessioned 2016-01-24T14:05:41Z
dc.date.available 2016-01-24T14:05:41Z
dc.date.issued 2010-11-05
dc.identifier http://dx.doi.org/10.1016/j.ijcard.2009.06.008
dc.identifier.citation International Journal of Cardiology. Clare: Elsevier B.V., v. 145, n. 1, p. 34-39, 2010.
dc.identifier.issn 0167-5273
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/33077
dc.description.abstract Background: Since the cell therapy benefits for myocardial infarction are mainly related to infarct reduction by regenerating lost myocardium or increasing survival of tissues at risk, we evaluated the effects of bone marrow-derived mononuclear cells (MNC), implanted after the completion of necrosis, on infarct progression and cardiac remodeling.Methods: After 48 h of induction of myocardial infarction (MI), Lewis-inbred rats were injected with 6 x 10(6) cells (MI + MNC) or saline (MI). After six weeks, scar dimension, ventricular morphology and function were analyzed by echocardiography followed by histomorphology of the infarcted and border zones.Results: After therapy, the relative size of the infarct was smaller in MI + MNC (37 +/- 1% of the left ventricle) than in MI (43 +/- 1%). While the MI group exhibited parallel elongation of the infarcted (31.6 +/- 3.8% increase) and reminiscent ventricular portions (33.5 +/- 3.7%), MNC therapy preserved the initial infarct length. Infarcted walls were thicker (979 +/- 31 mm) in the MNC group than in the untreated group (709 +/- 41 mm), also demonstrating an absence of infarct expansion. in the border zones, MNC led to increased capillary densities and capillary/myocyte ratios. the cardiac systolic function remained depressed in MI, but improved by 19 +/- 5% in MI + MNC which reduced the incidence of pulmonary arterial hypertension (37.5% in MI and 6.25% in MI + MNC).Conclusion: MNC therapy prevented the infarct expansion and thinning related to cardiac remodeling and was associated with an improvement of border zone microcirculation: as a result, MNC therapy reduced typical MI dysfunctional repercussions. (C) 2009 Elsevier Ireland Ltd. All rights reserved. en
dc.description.sponsorship Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorship Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent 34-39
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof International Journal of Cardiology
dc.rights Acesso restrito
dc.subject Stem cell en
dc.subject Capillary density en
dc.subject Myocardial infarction en
dc.subject Bone marrow en
dc.subject Rats en
dc.title Bone marrow cell therapy prevents infarct expansion and improves border zone remodeling after coronary occlusion in rats en
dc.type Artigo
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Universidade de São Paulo (USP)
dc.description.affiliation Universidade Federal de São Paulo, Dept Med, Div Cardiol, BR-04024900 São Paulo, SP, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Cardioresp Physiol Div, Dept Physiol, BR-04020041 São Paulo, SP, Brazil
dc.description.affiliation Univ São Paulo, Sch Med, Inst Heart InCor, BR-05403000 São Paulo, SP, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Med, Div Cardiol, BR-04024900 São Paulo, SP, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Cardioresp Physiol Div, Dept Physiol, BR-04020041 São Paulo, SP, Brazil
dc.identifier.doi 10.1016/j.ijcard.2009.06.008
dc.description.source Web of Science
dc.identifier.wos WOS:000283727000019



File

File Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

Search


Browse

Statistics

My Account